Genomics

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Microarray analysis of in vivo inhibition of mir-122 with an antisense oligonucleotide.


ABSTRACT: Current understanding of microRNA (miRNA) biology is limited, and antisense oligonucleotide (ASO) inhibition of miRs is a powerful technique for their functionalization. To uncover the role of the liver-specific miR-122 in the adult liver, we inhibited it in vivo using a 2’-O-methoxyethyl phosphorothioate ASO. This microrarray experiment was used to identify changes in mRNA levels due to the inhibition of miR-122 that accompanied phenotypic observations of reduced cholesterol and triglycerides, increased fatty acid oxidation, and decreased fatty acid and cholesterol synthesis rates observed in hepatocytes. Keywords: single treatment vs. control

ORGANISM(S): Mus musculus

PROVIDER: GSE3603 | GEO | 2006/03/01

SECONDARY ACCESSION(S): PRJNA93705

REPOSITORIES: GEO

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