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Identification of Xenotropic MuLV-related virus

ABSTRACT: This series includes 20 microarrays used to identify Xenotropic MuLV-related virus (XMRV) in a set of human prostate tumors associated with R462Q RNASEL variant (Urisman, et al. 2006). Keywords: viral detection

ORGANISM(S): Viruses

PROVIDER: GSE3607 | GEO | 2006/01/01

SECONDARY ACCESSION(S): PRJNA93711

REPOSITORIES: GEO

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Identification of Xenotropic MuLV-related virus

Project description:This series includes 20 microarrays used to identify Xenotropic MuLV-related virus (XMRV) in a set of human prostate tumors associated with R462Q RNASEL variant (Urisman, et al. 2006). The series includes 19 prostate tumor samples (VP) and a cell line control (HeLa).

2010-07-01 | E-GEOD-3607 | biostudies-arrayexpress

Human metapneumovirus strain associated with critical respiratory illness in an elderly male with leukemia Stanford HMPV

Project description:This series includes 1 microarray used to detect a human metapneumovirus strain associated with critical respiratory illness in an elderly male with leukemia (Chiu, et al 2006) Keywords: viral detection

2008-03-01 | GSE6214 | GEO

Optimization and Clinical Validation of a Pathogen Detection Microarray

Project description:This series includes microarrays from 36 patient samples and 2 cell-culture controls, used to optimize and validate the pathogen detection microarray (Wong, et. al. 2007) Keywords: viral pathogen detection

2007-05-29 | GSE7779 | GEO

SWCoV1 series; viral detection in Beluga whale liver

Project description:This series includes 3 microarrays used to detect SWCoV1, a novel group III coronavirus in Delphinapterus leucas (Beluga whale) liver. Keywords: viral detection

2008-04-15 | GSE9238 | GEO

Series1

Project description:This series includes 1 microarray used to detect parainfluenza 4a from an endotracheal aspirate from a patient with acute respiratory failure Keywords: viral detection

2006-05-01 | GSE4191 | GEO

Ribosome profiling of the retrovirus murine leukemia virus

Project description:Ribosome profiling (Ribo-Seq) (maps positions of translating ribosomes on the transcriptome) and RNA-Seq (quantifies the transcriptome) analysis of Rattus norvegicus cells infected with Moloney Murine Leukemia Virus (Mo-MuLV).

2018-01-17 | E-MTAB-6231 | biostudies-arrayexpress

Modeling lethal prostate cancer variant with small cell carcinoma features

Project description:This SuperSeries is composed of the following subset Series: GSE32967: Modeling lethal prostate cancer variant with small cell carcinoma features [expression profile] GSE33053: Modeling lethal prostate cancer variant with small cell carcinoma features [genomic profile] Refer to individual Series

2012-01-01 | E-GEOD-33054 | biostudies-arrayexpress

Series1

Project description:This series includes 1 microarray used to detect parainfluenza 4a from an endotracheal aspirate from a patient with acute respiratory failure The series includes 1 microarray used for viral detection using Viro3 viral detection platform

2010-07-01 | E-GEOD-4191 | biostudies-arrayexpress

[HPP-2.0] Prostate cancer specific library including 125 injections

Project description:prostate cancer FFPE samples includes 125 injections

2024-02-01 | PXD049071 | iProX

Heterozygous OAS1 Gain-of-Function Variants Cause a Polymorphic Autoinflammatory and Immunodeficiency Syndrome

Project description:Oligoadenylate synthase 1 (OAS1) is a type-1 interferon-inducible, intracellular double-stranded RNA (dsRNA) sensor that generates 2'-5'-oligoadenylate (2-5A) to activate RNaseL as a means of antiviral defense. We report four de novo heterozygous OAS1 variants in five patients. Variant OAS1 proteins show dsRNA-independent gain-of-function 2-5A synthetase activity that results in RNaseL-mediated RNA-cleavage, transcriptomic downregulation, and functional impairment and/or apoptosis of monocytes, iPSC-derived macrophages, and B-cells. This leads to a polymorphic syndrome of monocyte, macrophage, and B-cell deficiency characterized by autoinflammation, pulmonary alveolar proteinosis, and hypogammaglobulinemia. RNase-L-inhibition in vitro mitigates, and hematopoietic cell transplantation in vivo corrects the autoinflammatory and immunodeficiency phenotype.

2021-06-18 | GSE173667 | GEO

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