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S. aureus gene expression following growth in media containing oleic acid

ABSTRACT: S. aureus response to exogenous fatty acid (oleic acid) Gene expression profiles were generated by microarray analysis of S. aureus cells grown in media without or with oleic aicd

ORGANISM(S): Staphylococcus aureus subsp. aureus RN4220 Staphylococcus aureus

PROVIDER: GSE36231 | GEO | 2012/12/21

SECONDARY ACCESSION(S): PRJNA153141

REPOSITORIES: GEO

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S. aureus gene expression following growth in media containing oleic acid

Project description:S. aureus response to exogenous fatty acid (oleic acid) Gene expression profiles were generated by microarray analysis of S. aureus cells grown in media without or with oleic aicd Comparison of expression profiles after growth of S. aureus in exogenous fatty acid S. aureus was grown in media with and without oleic acid to an OD600nm of 0.5, and RNA was extracted to look at the gobal gene expression.

2012-12-21 | E-GEOD-36231 | biostudies-arrayexpress

Brassica napus high oleic acid vs. low oleic acid

Project description:Compared to ordinary rapeseed, high-oleic acid rapeseed has higher levels of monounsaturated fatty acids and lower levels of saturated fatty acid and polyunsaturated fatty acids, and thus is of high nutritional and health value. In addition, high-oleic acid rapeseed oil imparts cardiovascular protective effects. Based on these properties, high-oleic acid oil crops have been extensively investigated and cultivated. In this study, we employed a microarray analysis with high oleic acid line and low oleic acid line from the developing seeds (27 days after flowering) of Brassica napus.

2018-09-20 | GSE120223 | GEO

Brassica napus high oleic acid vs. low oleic acid

Project description:Brassica napus high oleic acid vs. low oleic acid

| PRJNA492174 | ENA

Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury

Project description:Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis elegans, and mice, we found that ferroptosis occurs in the context of iron-overload-mediated damage. Exogenous oleic acid protected against iron-overload-toxicity in cell culture and Caenorhabditis elegans by suppressing ferroptosis. In mice, oleic acid protected against FAC-induced liver lipid peroxidation and damage. Oleic acid changed the cellular lipid composition, characterized by decreased levels of polyunsaturated fatty acyl phospholipids and decreased levels of ether-linked phospholipids. The protective effect of oleic acid in cells was attenuated by GW6471 (a PPAR- antagonist), as well as in Caenorhabditis elegans lacking the nuclear hormone receptor NHR-49 (a PPAR- functional homologue). These results highlight ferroptosis as a driver of iron-overload-mediated damage, which is inhibited by oleic acid. This monounsaturated fatty acid represents a potential therapeutic approach to mitigating organ damage in iron overload individuals.

2023-10-02 | GSE243891 | GEO

Conditioned media from human pancreatic cancer cells reduces oleic acid oxidation in human myotubes

Project description:In the present study we wanted to metabolically compare healthy primary human pancreas epithelial cells (hPEC) to a pancreatic cancer cell line (PANC-1) and to explore the effect of exposing conditioned medium from the hPEC and PANC-1 cells on the energy metabolism in primary human myotubes. We studied differences in metabolism of glucose, oleic acid and lactic acid, as well as lactic acid production in the two pancreatic cell lines. Mass spectrometry-based proteomics was used to study global protein secretion from the two cell types and pathway analyses were performed. We observed that the PANC-1 cells did not exhibit a typical Warburg effect. Though they tended to have higher uptake of glucose and higher production of lactic acid, they also displayed a higher oxidation of glucose compared to hPEC cells. Interestingly, the PANC-1 cells had higher uptake but lower oxidation of oleic acid, and the mitochondrial reserve capacity from oleic acid was also lower in the PANC-1 cells. These changes in energy metabolism were reflected by differences in gene expressions, and differential expression of different pathways. Furthermore, conditioned media from the PANC-1 cells reduced the oleic acid oxidation in primary human skeletal muscle cells, but further studies will have to be conducted to reveal the mediator of this effect. Although this study is comparing a cancer cell line with a non-cancer cell line, we do not in any way imply that this represent cancer. This study merely represents the differences between the two different cell types studied.

2020-09-02 | PXD017613 | Pride

Staphylococcus aureus subsp. aureus RN4220

Project description:S. aureus gene expression following growth in media containing oleic acid

| PRJNA153141 | ENA

Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions

Project description:Comparing the transcriptomic program induced by oleic acid to that of the pro-inflammatory arachidonic acid, we find that Tregs sorted from peripheral blood and adipose of healthy donors transcriptomically resemble the oleic acid in vitro treated Tregs, whereas Tregs obtained from the adipose tissue of relapsing-remitting MS patients more closely resemble an arachidonic acid profile

2020-11-17 | GSE152543 | GEO

Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions (bulk RNA)

2020-11-17 | GSE151586 | GEO

Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide mediate signaling in plant defense.

Project description:Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide- mediate signaling in plant defense. Nitric Oxide, Oleic acid, Salicylic acid, Arabidopsis, Defense

2012-08-01 | GSE36797 | GEO

Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions (single-cell RNA)

2020-11-17 | GSE152197 | GEO

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