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Post-hepatitis C and post-alcoholism hepatocellular carcinomas: series 3

ABSTRACT: The aim of this study is to compare post-Hepatitis C (HCV) and post-Alcoholism (ALC) Hepatocellular Carcinoma gene expression profiling. Owing to transcriptome analysis with a cDNA array virtually covering every transcript in liver, we compared tumors vs paired cirrhosis or tumors vs controls as a function of etiology, i.e. alcoholism (ALC) vs hepatitis C virus (HCV). The so-called Significance Analysis of Microarray was used to identify those genes with the most informative changes in transcript levels. Comparisons of tumor/cirrhosis ratios or tumor/controls ratios between 12 alcoholic vs 10 HCV patients identified a total of 31 transcripts whose altered ratios appropriately clustered the patients according to etiology. Keywords: etiology analysis

ORGANISM(S): Homo sapiens

PROVIDER: GSE3632 | GEO | 2005/11/19

SECONDARY ACCESSION(S): PRJNA93745

REPOSITORIES: GEO

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