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Expression data from middle-aged and old Drosophila females

ABSTRACT: The mechanisms underlying natural variation in lifespan and ageing rate remain largely unknown. We performed microarray experiment to characterise genome-wide expression patterns of a long-lived, natural variant of Drosophila melanogaster resulting from selection for starvation resistance (SR) and compare it with normal-lived control flies (C).

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE36582 | GEO | 2012/04/01

SECONDARY ACCESSION(S): PRJNA153747

REPOSITORIES: GEO

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Expression data from middle-aged and old Drosophila females

Project description:The mechanisms underlying natural variation in lifespan and ageing rate remain largely unknown. We performed microarray experiment to characterise genome-wide expression patterns of a long-lived, natural variant of Drosophila melanogaster resulting from selection for starvation resistance (SR) and compare it with normal-lived control flies (C). We sampled adult females at two time points representing middle age (90% survival) and old age (10% survival) respectively, in three adult diets (malnutrition, optimal food, and overfeeding).

2012-03-31 | E-GEOD-36582 | biostudies-arrayexpress

Early cardiac ageing: Phenotypic and transcriptional transitions in young to middle-aged mice

Project description:While much research has focussed on advanced stages (and mechanisms) of ageing, this fundamental process may commence at a relatively early age, impacting organ function and resilience throughout the adult lifespan. In male C57BL/6 mice, multiple phenotypic and transcriptional features of cardiovascular ageing were evident from 16 weeks of age, well in advance of 'middle age'. Phenotypic changes include declining cardiac and coronary reserves and resistance to ischaemic insult. Gene changes support early constitutive stress together with a plateau in transcriptome responsiveness to ischaemia, and declining induction of cardioprotective and quality control pathways vs. increasing induction of genes promoting signalling dysfunction, hypertrophy and cell death. These findings support cardiac ageing from early adulthood. Molecular changes reflect declining adaptive capacity/quality control, consistent with evolutionary theories of biological ageing.

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rapamycin treatmented middle-aged mice

Project description:Transient rapamycin treatment robustly increases lifespan and healthspan in middle-aged mice

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Gene expression of young, middle-aged and old Drosophila melanogaster exposed to different levels of larval and adult diet

Project description:Many studies have addressed the effects of adult diet on gene expression in Drosophila melanogaster, however, little is known about how developmental diet influences adult gene expression, and how this interacts with adult dietary conditions. We found that developmental and adult diet exert largely independent effects on gene expression, with the effect of adult diet being considerably larger.We did find effects of developmental diet on the transcriptome that persist into middle and old-age. Most of the genes affected show no correlation with the observed phenotypic effects of larval diet on lifespan, however, in each sex we identified a cluster of ribosome, transcription, and translation-related genes whose expression was altered across the lifespan and negatively correlated with lifespan.

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Circadian expression data from epidermal stem cells from young and aged mice

Project description:Circadian adaptation is thought to have maximized organismal fitness by anticipating and synchronizing physiological functions to the day-night oscillations imposed by the rotation of the earth. The function of mammalian adult stem cells is under tight circadian control, and conditional deletion of the core clock component Bmal1 in murine tissues results in their premature ageing. In addition, complete Bmal1 and Clock knockout mice show a significantly shortened lifespan. However, it is not clear to what extent circadian disruption is causative of ageing. Moreover, if and how circadian oscillations are altered during physiological ageing in adult stem cells is not known.

2017-08-10 | GSE84511 | GEO

Spermidine Yeast Aging Array

Project description:Administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extends the lifespan of various model organisms including yeast, flies and worms. In ageing yeast, spermidine treatment triggeres epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), leading to induction of autophagy and thereby suppressing oxidative stress and necrosis. In order to further characterize the effects by spermidine supplementation of aging yeast cultures and to understand how global histone deacetylation affects gene transcription during aging, Affymetrix-based microarray analyses of three day old as well as ten day old cultures with and without administration of spermidine was performed.

2012-01-04 | E-MTAB-912 | biostudies-arrayexpress

Structural, biochemical, and molecular analyses of cambial stem cells reveal longevity mechanisms in old Ginkgo biloba trees

Project description:High-throughput RNA, sRNA and degradome sequencing were performed to identify a large number of mRNA, miRNAs and their targets in G. biloba cambium at different ages to provide useful information for uncovering the regulatory networks of ageing in long-lived old trees.

2018-09-08 | GSE119213 | GEO

Expression data from mid-aged decapping mutant C. elegans nematodes

Project description:Removal of the 5’ cap of mRNAs (decapping) is mainly catalyzed by a conserved holoenzyme, composed of the catalytic subunit DCP2 and its essential cofactor DCP1. Studies in C. elegans have shown that ageing is characterized by the accumulation of decapping factors in P-Bodies, and loss of DCAP-1/DCP1 or DCAP-2/DCP2 significantly shortens lifespan. However, the relationship between mRNA decapping and ageing remains elusive. Here we present a comparative microarray study that aims to uncover this link by identifying differentially expressed genes between wild type mid-aged worms (9 days old) and age-matched animals with reduced function of DCAP-1/DCP1.

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Longitudinal study of variation in body mass index in middle-aged UK females.

Project description: Not available

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The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: dog]

Project description:We used buccal samples from two different dog breeds with well established differences in average lifespan to perform genome-scale identification of ageing-associated differentially methylated positions (aDMPs) in a total of 48 different dogs. A significant proportion of aDMPs that gained methylation with age replicated in an independent cohort. Furthermore, we also show that human aDMPs show similar ageing-associated dynamics at the homologous genomic regions in the dog. The replicated aDMPs show a faster rate of change with age in the shorter lived dog species. Strikingly, these aDMPs also show a faster rate of change with age in dogs overall compared with humans.

2018-01-17 | GSE86058 | GEO

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