Genomics

Dataset Information

0

Genome wide binding sites of Smad3 and JMJD3 in neural stem cells


ABSTRACT: Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFβ pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. Overall, these findings indicate that JMJD3 function is required for the TGFβ developmental program to proceed.

ORGANISM(S): Mus musculus

PROVIDER: GSE36673 | GEO | 2012/05/30

SECONDARY ACCESSION(S): PRJNA153575

REPOSITORIES: GEO

Similar Datasets

| E-GEOD-36673 | biostudies-arrayexpress
2012-05-01 | GSE35361 | GEO
| E-GEOD-35361 | biostudies-arrayexpress
| E-MTAB-825 | biostudies-arrayexpress
| PRJEB2739 | ENA
2016-03-01 | GSE76557 | GEO
2016-04-30 | GSE69750 | GEO
2011-06-24 | GSE26858 | GEO
2022-12-24 | PXD037926 | Pride
| E-GEOD-38269 | biostudies-arrayexpress