Expression profiling of aging liver in low-fat diet mice

ABSTRACT: Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. To determine how our dietary intervention-based transcriptomic approach for predicting aging-regulatory genes compares to more traditional approach of using age-dependent transcriptional changes, we examined the hepatic gene expression changes in LF-fed mice during aging at 4, 8, 13 and 21 months.

ORGANISM(S): Mus musculus

PROVIDER: GSE36836 | GEO | 2012/03/28

SECONDARY ACCESSION(S): PRJNA156987

REPOSITORIES: GEO