Expression profiling of the effect of high-fat diet, low-fat diet, CR and exercise on mice liver

ABSTRACT: Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging process. We found that pathways transcriptionally correlated with diet-modulated lifespan and physiological changes were enriched for lifespan-modifying genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE36838 | GEO | 2012/03/28

SECONDARY ACCESSION(S): PRJNA156989

REPOSITORIES: GEO