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Genomic profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization

ABSTRACT: In this study, we investigated CNAs of 40 tumor samples from 25 patients, including 15 metastatic primary tumor (MPT), paired neck lymph-node metastasis (LNM) and 10 non-metastatic primary tumor (NMPT), by 44k oligonucleotide-based array comparative genomic hybridization (array CGH).

ORGANISM(S): Homo sapiens

PROVIDER: GSE36942 | GEO | 2013/09/08

SECONDARY ACCESSION(S): PRJNA157317

REPOSITORIES: GEO

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Genomic profiling of oral squamous cell carcinoma by array-based comparative genomic hybridization

Project description:In this study, we investigated CNAs of 40 tumor samples from 25 patients, including 15 metastatic primary tumor (MPT), paired neck lymph-node metastasis (LNM) and 10 non-metastatic primary tumor (NMPT), by 44k oligonucleotide-based array comparative genomic hybridization (array CGH). 15 MPT vs 15 LNM, 10 NMPT vs 15 LNM

2013-09-08 | E-GEOD-36942 | biostudies-arrayexpress

Genomic profiling of chromophobe renal cell carcinoma by array-based comparative genomic hybridization

Project description:In this study, we investigated CNAs of 4 tumor samples from 2 patients, including conventioanl chromophobe renal cell carcinoma(ChRCC), ChRCC with neuroendocrine differentiation and no-tumor region by 44k oligonucleotide-based array comparative genomic hybridization (array CGH).

2015-01-21 | GSE52641 | GEO

Genomic profiling of primary and metastatic clear cell renal cell carcinoma by array-based comparative genomic hybridization.

Project description:In this study, we investigated CNAs of 20 primary clear cell renal cell caricinomas (ccRCCs), 20 corresponding metastases and another subsets of 30 primary ccRCCs by 44k oligonucleotide-based array comparative genomic hybridization (array CGH).

2014-10-16 | GSE43477 | GEO

Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases

Project description:Background: Mortality rates of pancreatic cancer remain high, which is mainly due to advanced disease and metastasis. We hypothesized that DNA copy number alteration are enriched in metastatic cells compared to autologous primary tumors, which may inform on cancer-related pathways possibly serving as potential targets for specific therapies. We investigated 18 pancreatic ductal adenocarcinomas, including 39 lymph node and 5 distant metastases after surgical resection. Analysis was performed with array-based comparative genomic hybridization. Results: Metastases acquire a higher frequency of CNAs with the highest in distant metastasis (OM: median=42, LNM: median=23, PT: median=17). In LNM, gains were prevalent on chromosome bands 8q11.23-q24.3, 12q14.1, 17p12.1, 21q22.12, and losses on 3p21.31, 4p14, 8p23.3-p11.21,17p12-11.2. Genes on amplified regions are involved in cancer-related pathways such as WNT-signaling, also involved in metastasis. Conclusions: Pancreatic cancers show a high degree of intratumor heterogeneity, which could lead to resistance of chemotherapy and worse outcome. ACGH analysis reveals regions preferentially gained or lost in synchronous metastases encoding for genes involved in cancer-related pathways, which could lead to novel therapeutic opportunities.

2017-10-01 | GSE103787 | GEO

Genomic profiling of chromophobe renal cell carcinoma by array-based comparative genomic hybridization

2015-01-21 | E-GEOD-52641 | biostudies-arrayexpress

Genomic profiling of primary and metastatic clear cell renal cell carcinoma by array-based comparative genomic hybridization.

2014-10-16 | E-GEOD-43477 | biostudies-arrayexpress

Intratumoral genomic heterogeneity in submucosal-invasive gastric cancer

Project description:In this study, we investigated CNAs of 59 tumor samples from 27 patients with submucosal-invasive gastric cancers (SMGC) by 44k oligonucleotide-based array comparative genomic hybridization (array CGH).

2012-01-20 | GSE26800 | GEO

Array comparative genomic hybridization of Canine Oral Melanoma (COM) archival samples.

Project description:The aim of this work was to identify the Copy Number Aberrations (CNAs) by high-resolution array Comparative Genomic Hybridization (aCGH) on 19 formalin-fixed, paraffin-embedded (FFPE) samples of treatment-naïve COM.

2020-01-13 | GSE131923 | GEO

Genomic profiling of gastric adenomas by array-based comparative genomic hybridization

Project description:In this study, we investigated CNAs of 20 gastric CIS (Vienna category 4.2) and 20 adenomas, including 7 low-grade adenomas (LGA; Vienna category 3) and 13 high-grade adenomas (HGA; Vienna category 4.1), by 244k oligonucleotide-based array comparative genomic hybridization (array CGH).

2010-02-01 | GSE19574 | GEO

Genomic profiling of gastric carcinoma in situ by array-based comparative genomic hybridization

2010-02-01 | GSE19566 | GEO

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