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Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE37030 | GEO | 2012/05/21

SECONDARY ACCESSION(S): PRJNA157847

REPOSITORIES: GEO

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Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.

Project description: Not available

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Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages

Project description:This SuperSeries is composed of the following subset Series: GSE37028: Microarray analysis of Zbtb46 KO CD4+ Splenic DCs and bone marrow erythroid progenitors GSE37029: Microarray analysis of WT bone marrow myeloid progenitors, BM cultured with GM-CSF and M-CSF, and monocytes treated with GM-CSF Refer to individual Series

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Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin.

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zDC (Zbtb46, Btbd4) knockout classical dendritic cells

Project description:Classical dendritic cells (cDCs) process and present antigens to T cells. Under steady-state conditions, antigen presentation by cDCs induces tolerance. In contrast, during infection or inflammation, cDCs become activated, express higher levels of cell surface MHC molecules, and induce strong adaptive immune responses. We recently identified a cDC-restricted zinc finger transcription factor, zDC, that is not expressed by other immune cell populations, including pDCs, monocytes, or macrophages. Here we define the zDC consensus DNA binding motif and the genes regulated by zDC using chromatin immunoprecipitation and deep sequencing. By deleting zDC from the mouse genome, we show that zDC is primarily a negative regulator of cDC gene expression. zDC deficiency alters the cDC subset composition in the spleen in favor of CD8+ DCs, upregulates activation pathways in steady state cDCs including elevated MHC II expression, and enhances cDC production of VEGF leading to increased vascularization of skin-draining lymph nodes. Consistent with these observations, zDC protein expression is rapidly downregulated after TLR ligation. Thus, zDC is a TLR-responsive cDC-specific transcriptional repressor that is in part responsible for preventing cDC maturation in the steady state.

2012-07-16 | GSE37995 | GEO

zDC (Zbtb46, Btbd4) knockout classical dendritic cells

2012-07-15 | E-GEOD-37995 | biostudies-arrayexpress

Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.

Project description: Not available

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Notch2-dependent classical dendritic cells orchestrate intestinal immunity against attaching and effacing bacterial pathogens

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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CD66b-CD64dimCD115- cells in the human bone marrow represent neutrophil-committed progenitors

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-11 | GSE164687 | GEO