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Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart2]

ABSTRACT: Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

ORGANISM(S): Homo sapiens

PROVIDER: GSE37117 | GEO | 2012/12/10

SECONDARY ACCESSION(S): PRJNA159447

REPOSITORIES: GEO

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Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart3]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

2012-12-10 | GSE37116 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart1]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence

2012-12-10 | GSE37110 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte

Project description:Single embryo transfer (SET) is the most successful way to reduce the frequency of multiple pregnancies during in vitro fertilisation. However, selecting the embryo with the highest chances of pregnancy for SET remains a difficult challenge, since morphological and kinetics criteria provide poor prediction of both developmental and implantation ability. Partly through the expression of specific genes, the oocyte-cumulus interaction helps the oocyte to acquire its developmental competence. Our aim was therefore to identify at the level of cumulus cells (CCs) any genes related to oocyte developmental competence. This SuperSeries is composed of the SubSeries listed below. Refer to individual Series.

2012-12-10 | E-GEOD-37277 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte

2012-12-10 | GSE37277 | GEO

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart3]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence 2-condition experiment: blastocyst (B) AND embryo of poor quality (E).

2012-12-10 | E-GEOD-37116 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart2]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence 2-condition experiment: blastocyst (B) ans embryo of poor quality (E).

2012-12-10 | E-GEOD-37117 | biostudies-arrayexpress

Differentiating factors of cumulus cells related to quality of the human oocyte [CadoretPart1]

Project description:Our aim was to identify at the level of cumulus cells any genes related to oocyte developmental competence three-condition experiment: blastocyst (B), embryo of poor quality (E) AND immature oocytes (VG).

2012-12-10 | E-GEOD-37110 | biostudies-arrayexpress

The bovine cumulus proteome of cumulus oocyte complexes that successfully matured or failed to mature after maturation in-vitro and in-vivo

Project description:The oocyte forms a complex with their somatic cumulus cells within the follicle throughout the preovulatory maturation steps. Cumulus cells support their oocyte not only through mechanical protection but also with a close bidirectional exchange of metabolites. Analysis of the oocytes cumulus gives the opportunity to explore non-invasively oocytal well-being and quality. In vitro maturation (IVM) is the first rate-limiting step in in vitro embryo production. Analysis of protein expression in cumulus cells around this critical step helps to explore the impact of maturation conditions and to examine an influence on maturational competence of the oocyte. The goal of this study was the comparison of the cumulus proteome of oocytes with and without maturational competence matured under in vivo and in vitro conditions. Therefore twenty cumulus samples corresponding to single oocytes were analysed. Half of the samples were matured in vivo and the other half in vitro. For each maturation group, cumulus from oocytes matured successfully (SM; n=5) and failed to mature (FM; n=5) were analysed.

2020-06-30 | PXD016679 | Pride

Gene expression profiling of in vitro matured bovine oocytes cultivated with or without cumulus cells.

Project description:Cumulus cells, surrounding the oocyte, play a key role in the acquisition of oocyte competence to be fertilized and to sustain early embryo development. Cumulus cells contribute to oocyte development by metabolizing energy substrates such as glutathione that may protect the oocyte from oxidative stress damages. The aim of our study was to compare transcriptomics profiles of cumulus enclosed (CEO) and cumulus denuded (CDO) oocytes after in vitro maturation.

2011-08-17 | GSE31361 | GEO

RNA‐sequencing reveals genes linked with oocyte developmental potential in bovine cumulus cells

Project description:Cumulus cells provide an interesting biological material to perform analyses to understand the molecular clues determining oocyte competence. The objective of this study was to analyze the transcriptional differences between cumulus cells from oocytes exhibiting different developmental potentials following individual in vitro embryo production by RNA‐seq. Cumulus cells were allocated into three groups according to the developmental potential of the oocyte following fertilization: (1) oocytes developing to blastocysts (Bl+), (2) oocytes cleaving but arresting development before the blastocyst stage (Bl-), and (3) oocytes not cleaving (Cl-).

2024-03-12 | GSE261131 | GEO

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