Transcriptomics

Dataset Information

52

MTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma


ABSTRACT: The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial. Overall design: Comparative study of total RNA obtained from normal and tumor liver tissue under RAD001, BEZ235, or RAD001 + BEZ235.

INSTRUMENT(S): Illumina MouseRef-8 v2.0 expression beadchip

ORGANISM(S): Mus musculus  

SUBMITTER: Manway Liu  

PROVIDER: GSE37129 | GEO | 2012-07-12

SECONDARY ACCESSION(S): PRJNA158305

REPOSITORIES: GEO

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