Genomics

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MTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma


ABSTRACT: The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial.

ORGANISM(S): Mus musculus

PROVIDER: GSE37129 | GEO | 2012/07/12

SECONDARY ACCESSION(S): PRJNA158305

REPOSITORIES: GEO

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