Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide

ABSTRACT: The purpose of this study is to search for aberrant genes in HaCaT keratinocytes after chronic exposure to arsenic trioxide. The objective of the investigation was to discover the mechanism of arsenic carcinogenicity in human epidermal keratinocytes. We hypothesize that a combined strategy of DNA microarray, qRT-PCR and gene function annotation will identify aberrantly expressed genes in HaCaT keratinocyte cell line after chronic treatment with arsenic trioxide. HaCaT cells were chronically exposed to 0.5µg/mL arsenic trioxide (As2O3) up to 22 passages and RNA was extracted. Microarray data analysis identified 14 up-regulated genes and 21 down-regulated genes in response to arsenic trioxide

ORGANISM(S): Homo sapiens

PROVIDER: GSE37192 | GEO | 2012/04/12

SECONDARY ACCESSION(S): PRJNA158983

REPOSITORIES: GEO