Project description:the gene expression profiling results provide important information for the genes regulated by crosstalk between Shp2 and Pten mediated signal pathways Total RNA was extracted from CD71mid Ter119high erythroblasts isolated from the bone marrow of wide type, Shp2 knock-out, Pten knock-out and double knock-out mice
Project description:Our study focuses on searching for novel genes involved in cholesterol metabolism through genome-wide screening, RNA-seq, proteome and lipidomic.This project maily focus on the proteomics of LDLR and HMGCR double knock out human HepG2 cells.