Effects of Brca1 knock-down on Ezh2 targeting

ABSTRACT: The Polycomb repressive complex 2 (PRC2) is important for the maintenance of stem cell pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 trimethylation (H3K27me3) and silencing expression of genes regulating differentiation. Here we show decreased expression of BRCA1 promotes EZH2 re-targeting genome wide and enhances H3K27me3 levels at PRC2 target loci in mouse ES cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE37321 | GEO | 2013/07/01

SECONDARY ACCESSION(S): PRJNA159573

REPOSITORIES: GEO