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Analysis of gene expression of Peripheral Blood Mononuclear Cells (PBMC) in Systemic Juvenile Idiopathic Arthrits (sJIA)

ABSTRACT: sJIA patients were recruited through the Stanford Pediatric Rheumatology Clinic. All sJIA study subjects met amended ILAR criteria for the diagnosis of SJIA. The study was approved by the Stanford Institutional Review Board.

ORGANISM(S): Homo sapiens

PROVIDER: GSE37388 | GEO | 2012/09/06

SECONDARY ACCESSION(S): PRJNA159715

REPOSITORIES: GEO

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Analysis of gene expression of Peripheral Blood Mononuclear Cells (PBMC) in Systemic Juvenile Idiopathic Arthrits (sJIA)

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2012-09-06 | E-GEOD-37388 | biostudies-arrayexpress

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Project description:Canakinumab is a human anti-interleukin-1 beta (IL-1 beta) monoclonal antibody neutralizing IL-1 beta. Systemic juvenile idiopathic arthritis (SJIA) is a rare, multigenic, autoinflammatory disease of unknown etiology characterized by chronic arthritis; intermittent high-spiking fever, rash, and elevated levels of acute-phase reactants. Blood samples of SJIA patients were obtained from two phase 3 clinical trials conducted by the members of the Pediatric Rheumatology International Trials Organization (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG) (Clinicaltrials.gov: NCT00886769 and NCT00889863). For patients, baseline and day 3 samples were analyzed for either placebo or canakinumab (Ilaris) treatment. Clinical response was assessed at day 15 using adapted JIA American College of Rheumatology (ACR) response criteria.

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Transcriptome analysis by RNA-seq of ovarian cancer derived from the Cancer Institute Hospital of Japanese Foundation for Cancer Research.

Project description:We performed the RNA-seq experiments for mRNA of ovarian cancer tissue. Raw data not provided. Institutional Review Board (IRB) does not allow submitters to disclose raw data to the public

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