Butyrophilin 3A1 binds phosphorylated antigens and stimulates human TCR γδ cells.

ABSTRACT: We used genetic approaches to identify butyrophilin 3A1 (BTN3A1) as the molecule that binds and presents phosphorylated antigens to Vγ9Vδ2 TCR–expressing cells. BTN3A1 represents a novel antigen–presenting molecule for the activation of Vγ9Vδ2 TCR–expressing cells which play important roles in human tumor immunity and host defense.

ORGANISM(S): Homo sapiens

PROVIDER: GSE37634 | GEO | 2012/10/01

SECONDARY ACCESSION(S): PRJNA162417

REPOSITORIES: GEO