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Expression data from mouse embryonic stem cells upon TRIM71 KD and parental ctrl cells

ABSTRACT: We identify mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability. In this data set we compare the expression profile of mouse ES upon Trim71 KD versus that of the parental cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE37712 | GEO | 2013/01/22

SECONDARY ACCESSION(S): PRJNA162911

REPOSITORIES: GEO

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Expression data from mouse embryonic stem cells upon TRIM71 KD and parental ctrl cells

Project description:We identify mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability. In this data set we compare the expression profile of mouse ES upon Trim71 KD versus that of the parental cells. Experiment was performed in triplicate.

2013-01-22 | E-GEOD-37712 | biostudies-arrayexpress

Expression data from HEK293 Flp-In cells constitutivly expressing FLAG-HA-tagged TRIM71 and that of the parental cell line

Project description:We identify mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability. In this data set we compare the expression profile of human HEK293 Flp-In cells stably expressing TRIM71 to that of the parental cells, not expressing TRIM71 protein. Experiment was performed in triplicate.

2013-01-22 | E-GEOD-37713 | biostudies-arrayexpress

Expression data from HEK293 Flp-In cells constitutivly expressing FLAG-HA-tagged TRIM71 and that of the parental cell line

Project description:We identify mammalian TRIM71 as repressor of mRNAs that inhibits translation and affects mRNA stability. In this data set we compare the expression profile of human HEK293 Flp-In cells stably expressing TRIM71 to that of the parental cells, not expressing TRIM71 protein.

2013-01-22 | GSE37713 | GEO

mRNA sequencing of Trim71 conditional ("WT") and Trim71 KO mES cells

Project description:We report that Trim71 mutation does not lead to significant changes within the core regulatory network of mES cells, however, there is an upregulation of specific genes involved in neural differentiation. We thus conclude that Trim71 KO mES cells are poised for differentiation.

2015-10-01 | GSE62398 | GEO

Studies on Trim71 in mouse embryonic stem cells

Project description:We studies on Trim71 regulates mouse embryonic stem cells by identifying the transcriptome-wide RNA targets of Trim71. Moreover, through inhibiting specific Trim71:mRNA interactions, we determined how Trim71 modulate miRNA activity in mouse embryonis cell cells

2021-02-23 | GSE138284 | GEO

Proteome of C. elegans upon NCL-1 or TIF-IA KD during aging

Project description:Anabolic activities such as ribosome biogenesis and protein synthesis are linked to aging. Ribosomal RNA (rRNA) synthesis is the limiting step of ribosome biogenesis, thus dictating the number of ribosomes in cells and, consequently, the capacity for mRNA translation. Knockdown of the rRNA synthesis repressor, NCL-1, accelerated aging, whereas knocking down the transcription initiation factor C36E8.1 promoted longevity. This suggested that rRNA synthesis has a negative correlation with lifespan. To investigate the metabolic changes upon manipulation of rRNA synthesis the proteome of NCL-1 KD and C36E8.1 KD were analyzed at young, middle, and old age (AD2, AD6, AD12).

2024-01-11 | PXD028600 | Pride

Studies on a hydrocephalus-causing mutation on Trim71

Project description:We studies on how a hydrocephalus-causing mutation (R783H) on Trim71 alters Trim71's substrate mRNA binding

2022-11-04 | GSE183715 | GEO

The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1

Project description:We demonstrate that global effects of TRIM71 on the cellular transcriptome of mouse embryonic stem cells (mESCs) are largely attributable to its RNA binding activity, and map the transcriptome-wide targets of wild-type TRIM71, NHL domain mutant TRIM71, and RING domain mutant TRIM71.

2019-08-01 | GSE130248 | GEO

Studies on the R595H hydrocephalus-associated mutation on Trim71

Project description:We studies on how a hydrocephalus-associated mutation (R595H) on Trim71 alters Trim71's substrate mRNA binding

2022-05-07 | GSE201945 | GEO

miRNA sequencing of Trim71 conditional ("WT") and Trim71 KO mES cells

Project description:We report that Trim71 mutation induces significant changes in the global expression profile of miRNAs in undifferentiated mES cells, rendering the cells prone to differentiation.

2015-10-01 | GSE62509 | GEO

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