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Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Merkel cell polyomavirus Mus musculus Rattus norvegicus JC polyomavirus Betapolyomavirus macacae Human gammaherpesvirus 8 Homo sapiens Human immunodeficiency virus 1 Murid gammaherpesvirus 4 Human betaherpesvirus 5 Human alphaherpesvirus 2 Human alphaherpesvirus 1 Betapolyomavirus hominis human gammaherpesvirus 4 Mus musculus cytomegalovirus 2

PROVIDER: GSE37788 | GEO | 2012/05/06

SECONDARY ACCESSION(S): PRJNA163349

REPOSITORIES: GEO

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Identification of XMRV infection-associated microRNAs in four cell types in culture.

Project description:IntroductionXMRV is a gammaretrovirus that was thought to be associated with prostate cancer (PC) and chronic fatigue syndrome (CFS) in humans until recently. The virus is culturable in various cells of human origin like the lymphocytes, NK cells, neuronal cells, and prostate cell lines. MicroRNAs (miRNA), which regulate gene expression, were so far not identified in cells infected with XMRV in culture.MethodsTwo prostate cell lines (LNCaP and DU145) and two primary cells, Peripheral Blood Lymphocytes [PBL] and Monocyte-derived Macrophages [MDM] were infected with XMRV. Total mRNA was extracted from mock- and virus-infected cells at 6, 24 and 48 hours post infection and evaluated for microRNA profile in a microarray.ResultsMicroRNA expression profiles of XMRV-infected continuous prostate cancer cell lines differ from that of virus-infected primary cells (PBL and MDMs). miR-193a-3p and miRPlus-E1245 observed to be specific to XMRV infection in all 4 cell types. While miR-193a-3p levels were down regulated miRPlus-E1245 on the other hand exhibited varied expression profile between the 4 cell types.DiscussionThe present study clearly demonstrates that cellular microRNAs are expressed during XMRV infection of human cells and this is the first report demonstrating the regulation of miR193a-3p and miRPlus-E1245 during XMRV infection in four different human cell types.

| S-EPMC3306368 | biostudies-literature

Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture

Project description:This SuperSeries is composed of the following subset Series: GSE37786: Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture (Experiment A) GSE37787: Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture (Experiment B) Refer to individual Series

2012-05-05 | E-GEOD-37788 | biostudies-arrayexpress

Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture (Experiment B)

Project description:XMRV is a gammaretrovirus that was thought to be associated with prostate cancer (PC) and chronic fatigue syndrome (CFS) in humans until recently. The virus is culturable in various cells of human origin like lymphocytes, NK cells, neuronal cells, and prostate cell lines. MicroRNAs (miRNAs), which regulate gene expression, were so far not identified in cells infected with XMRV in culture. Two prostate cancer cell lines (LNCaP and DU145) and two primary cells (peripheral blood lymphocytes (PBLs) and monocyte-derived macrophages (MDMs)) were infected with XMRV. Total mRNA was extracted from mock- and virus-infected cells at 6, 24 and 48 hours post-infection and evaluated for microRNA profile in a microarray. MicroRNA expression profiles of XMRV-infected continuous prostate cancer cell lines differ from that of virus-infected primary cells (PBLs and MDMs). miR-193a-3p and miRPlus-E1245 were observed to be specific to XMRV infection in all 4 cell types. While miR-193a-3p levels were down-regulated, miRPlus-E1245 on the other hand exhibited varied expression among the 4 cell types. The present study demonstrates that cellular microRNAs are expressed during XMRV infection of human cells. This is the first report demonstrating the regulation of miR193a-3p and miRPlus-E1245 during XMRV infection in four different human cell types.

2012-05-06 | GSE37787 | GEO

Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture (Experiment A)

2012-05-06 | GSE37786 | GEO

Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture (Experiment B)

2012-05-05 | E-GEOD-37787 | biostudies-arrayexpress

Identification of XMRV Infection-Associated microRNAs in Four Cell Types in Culture (Experiment A)

2012-05-05 | E-GEOD-37786 | biostudies-arrayexpress

Identification of microarray probe signals constantly present in multiple sample types

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-10 | E-GEOD-39528 | biostudies-arrayexpress

Efficient identification of microRNAs for classification of tumor origin

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series