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ChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells

ABSTRACT: ChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE37863 | GEO | 2012/12/11

SECONDARY ACCESSION(S): PRJNA164739

REPOSITORIES: GEO

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ChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells

Project description:ChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells MLE, MSL3 amd MOF ChIP in Drosophila S2 cells. 1-5 biological replicates per experiment. dye-swaps as indicated in sample description

2012-12-11 | E-GEOD-37863 | biostudies-arrayexpress

ChIP-Seq profiles of MSL1, MSL2, MSl3, MOF, MLE, H4K16ac and RNA Polymerase II phosphorlyated on Serine 5 in Drosophila S2 cells

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2012-12-11 | E-GEOD-37864 | biostudies-arrayexpress

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MLE ChIP-seq

Project description:Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) was carried out on wild-type Schneider (S2) cells using specific MLE antibodies to identify binding sites for MLE in the Drosophila genome

2013-10-30 | E-MTAB-1705 | biostudies-arrayexpress

MLE HITS-CLIP in Drosophila S2 cells

Project description:HITS-CLIP was carried out on wild-type Schneider (S2) cells using specific MLE antibodies to identify binding sites for MLE in the Drosophila transcriptome

2013-10-30 | E-MTAB-1706 | biostudies-arrayexpress

Drosophila melanogaster

Project description:ChIP-chip profiles of MLE, MSL3 and MOF in Drosophila S2 cells

| PRJNA164739 | ENA

Chromatin immunoprecipitation to determine MSL1, MSL3, MOF and H4K16Ac binding in Drosophila SL2 and Kc cells reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila

Project description:Genome-wide binding profiles of MSL1, MSL3, MOF and H4K16Ac in Drosophila SL2 and Kc cells.

2008-06-12 | E-MEXP-1508 | biostudies-arrayexpress

MLE ChIP-seq

Project description:MLE ChIP-seq

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Chromosomal High Affinity Binding Sites for the Drosophila Dosage Compensation Complex.

Project description:We identified 131 high affinity sites of the Drosophila DCC combining residual ChIP-chip profiles after differential crosslinking and RNAi-mediated knockdown of spreading factors Keywords: ChIP-chip MSL1 and MSL2 ChIP under various conditions including differential crosslinking and RNAi against MOF, MLE and MSL3. 2-4 replicates per experiment. dye-swaps as indicated in sample description.

2008-12-13 | E-GEOD-12292 | biostudies-arrayexpress

The interaction of MLE with CLAMP zinc finger domains is important for dosage compensation in Drosophila melanogaster

Project description:The Drosophila male-specific lethal (MSL) complex binds to the male X chromosome to activate transcription, and consists of five proteins, MSL1, MSL2, MSL3, MOF, MLE, and two roX RNAs. The MLE helicase remodels the roX lncRNAs, enabling the lncRNA-mediated assembly of the Drosophila dosage compensation complex. MSL2 is expressed only in males and interacts with the N-terminal zinc-finger of the transcription factor CLAMP that is important for specific recruitment of the MSL complex on the male X chromosome. Here we found that the unstructured C-terminal region of MLE interacts with 6-7 zinc-finger domains of CLAMP. In vitro 4-5 zinc fingers are critical for specific DNA-binding of CLAMP with GA-repeats, which constitute the core motif at the high affinity binding sites for MSL proteins. Deletion of the Clamp Binding Domain (CBD) in MLE results in decreasing of MSL proteins association with male X chromosome and increasing of male lethality. These results suggest that interactions of unstructured regions in MSL2 and MLE with CLAMP zinc finger domains are important for the specific recruitment of the MSL complex on the male X chromosome.

2024-03-20 | GSE239354 | GEO

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