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Zur regulon of Neisseria meningitidis

ABSTRACT: The zur regulon in Neisseria meningitidis was elucidated in the strain MC58 using a zur knockout strain and conditions which activate Zur ( zinc supplementation in the medium)

ORGANISM(S): Neisseria meningitidis

PROVIDER: GSE38033 | GEO | 2012/10/05

SECONDARY ACCESSION(S): PRJNA167086

REPOSITORIES: GEO

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Zur regulon of Neisseria meningitidis

Project description:The zur regulon in Neisseria meningitidis was elucidated in the strain MC58 using a zur knockout strain and conditions which activate Zur ( zinc supplementation in the medium) Common reference design, zur knock out strain was used as the common reference and the samples wild type strain grown in RPMI and in RPMI with Zinc supplementation were compared to the common reference.

2012-10-05 | E-GEOD-38033 | biostudies-arrayexpress

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Determination of the FarR regulon

Project description:Whole genome DNA microarray of Neisseria meningitidis serogroup B strain MC58 and the isogenic mutant strain deficient of the transcriptional regulator FarR, MC58 ∆farR.

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Transcriptional profiling of NMB0419 mutant of Neisseria meningitidis MC58

Project description:Neisseria meningitidis is an obligate commensal colonising the human nasopharynx and occasionally invades the bloodstream causing life-threatening meningitis and septicaemia. The gene NMB0419 on the genome of N. meningitidis MC58 encodes a putative Sel1-like repeat (SLR) containing protein, which has been implicated in mediating meningococcal invasion of epithelial cells. We prepared RNA samples from N. meningitidis MC58 (WT) and its isogenic mutant of NMB0419 grown to log phase in in-vitro culture. The RNA samples were subjected to RNA sequencing. The resulting transcriptomes were compared to determine the genes that differentially expressed in NMB0419 mutant.

2017-03-07 | GSE81572 | GEO

Transcriptome analysis of Neisseria meningitidis strain MC58 in GC medium

Project description:Transcriptome analysis of Neisseria meningitidis strain MC58 during a time course growth in GC medium

2011-06-09 | E-TABM-1113 | biostudies-arrayexpress

Comparative genomic hybridization of one Neisseria cinerea, two Neisseria lactamica, two Neisseria gonorrhoeae, and 48 Neisseria meningitidis isolates

Project description:Microarray comparative genome hybridization (mCGH) data was collected from one Neisseria cinerea, two Neisseria lactamica, two Neisseria gonorrhoeae, and 48 Neisseria meningitidis isolates. For N. meningitidis, these isolates are from diverse clonal complexes, invasive and carriage strains, and all major serogroups. The microarray platform represented N. meningitidis strains MC58, Z2491, and FAM18 and N. gonorrhoeae FA1090.

2007-04-04 | E-TIGR-129 | biostudies-arrayexpress

Transcription profiling of Neisseria gonorrhoeae and Neisseria meningitidis grown at different temperatures

Project description:Wild type Neisseria gonorrhoea strain FA1090 and N. meningitidis strain MC58 were grown on normal GC plate at either 35 degree celsius (for control samples) or 40 degree celsius (for test samples)

2007-11-20 | E-MEXP-590 | biostudies-arrayexpress

Transcriptome analysis of Neisseria meningitidis strain MC58 in human whole blood

Project description:Transcriptome analysis of Neisseria meningitidis strain MC58 during a time course growth in human whole blood

2011-06-09 | E-TABM-1115 | biostudies-arrayexpress

The phosphoproteome of choroid plexus epithelial cells following infection with Neisseria meningitidis

Project description:The Gram-negative bacterium Neisseria meningitidis causes meningitis in humans and has been demonstrated to manipulate or alter host signalling pathways during infection of the central nervous system. In this study, the phosphoproteome of an in vitro model of the blood-cerebrospinal fluid barrier was investigated during infection with the Neisseria meningitidis serogroup B (NmB) strain MC58 in presence and absence of the bacterial capsule. We show that the capsule deficient mutant has a higher impact on the phosphoproteome of the infected cells and identify potentially regulated pathways and cellular processes during infection.

2023-03-31 | PXD038560 | Pride

Transcription profiling of Neisseria meningitidis strain MC58 grown on RPMI agar containing 10uM Transferrin, 10uM Lactoferrin, 1uM Haemoglobin, or 20uM Ferric chloride

Project description:Transcriptional profiling of Neisseria meningitidis strain MC58 grown on RPMI agar containing 10uM Transferrin, 10uM Lactoferrin, 1uM Haemoglobin, or 20uM Ferric chloride.

2009-02-25 | E-MEXP-1143 | biostudies-arrayexpress

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