The zebrafish embryo as an alternative model for the evaluation of liver toxicity using histopathology and expression profiling

ABSTRACT: The zebrafish is as a powerful vertebrate model system for modeling human disease including liver pathology. In ZFE, hepatic responses can be expected after exposure to hepatotoxicants, because hepatocytes are present from 36-hpf and at 72-hpf the liver is fully functioning. These characteristics make the whole ZFE an attractive alternative model for compound-induced hepatotoxicity screening. Therefore, the main objective of this study is to further strengthen the applicability of whole ZFE as an alternative model for hepatotoxicity testing, with a special focus on the ability to identify gene expression responses in whole ZFE that are suggestive of hepatotoxicity. Deep sequence technology is applied to assess whether hepatotoxicity-specific transcripts that are identified in livers of hepatotoxicant treated adult zebrafish can be detected in whole ZFE as well.

ORGANISM(S): Danio rerio

PROVIDER: GSE38042 | GEO | 2015/05/15

SECONDARY ACCESSION(S): PRJNA167126

REPOSITORIES: GEO