Expression data from HCT116 colorectal cancer cells.

ABSTRACT: To define the contribution of CDK8 versus CDK19 to gene expression control, we performed a series of microarray assays for cells where each kinase was stably knocked down. Toward this end, we subjected HCT116 cells to three different stress stimuli: 5-fluorouracil (5FU), glucose deprivation, and hypoxia. We found that CDK8, but not CDK19, functions as a widespread coactivator of HIF1A target genes in hypoxia.

ORGANISM(S): Homo sapiens

PROVIDER: GSE38061 | GEO | 2013/03/01

SECONDARY ACCESSION(S): PRJNA167178

REPOSITORIES: GEO