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Gene expression data from teratomas formed by human iPSCs (chiPS) in SCID (Severe combined immunodeficiency) mice and humanized SCID mice (HuSCID)

ABSTRACT: Human fetal liver fibroblast were reprogrammed to chiPS without exogenous DNA integration using a single episomal vector. The chiPS were then transplanted into SCID mice and HuSCID to form teratomas. We used microarrays to profile the gene expression differences between the teratomas formed by chiPS in SCID and HuSCID mice.

ORGANISM(S): Homo sapiens

PROVIDER: GSE38069 | GEO | 2012/05/21

SECONDARY ACCESSION(S): PRJNA167182

REPOSITORIES: GEO

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Gene expression data from teratomas formed by human iPSCs (chiPS) in SCID (Severe combined immunodeficiency) mice and humanized SCID mice (HuSCID)

Project description:Human fetal liver fibroblast were reprogrammed to chiPS without exogenous DNA integration using a single episomal vector. The chiPS were then transplanted into SCID mice and HuSCID to form teratomas. We used microarrays to profile the gene expression differences between the teratomas formed by chiPS in SCID and HuSCID mice. Pooled total RNA from two teratomas formed by chiPS in SCID and HuSCID mice respectively were used for hybridization on Affymetrix microarrays.

2012-05-20 | E-GEOD-38069 | biostudies-arrayexpress

Gene expression data from teratomas formed by C57BL/6 (B6) ES and EiPS cells in B6 mice

Project description:Embryonic fibroblast from C57BL/6 (B6) mice were reprogrammed to EiPS without exogenous DNA integration using an single episomal vector. The EiPS cells and B6 ES cells were then transplanted into B6 mice to form teratomas. We used microarrays to profile the gene expression differences between the teratomas formed by B6 ES cells and EiPS cells. Pooled RNA from two teratomas formed by B6 ES or two regression teratomas formed by EiPS were selected for hybridization on Affymetrix microarrays.

2011-04-13 | E-GEOD-28573 | biostudies-arrayexpress

Gene expression data from teratomas formed by C57BL/6 (B6) ES and EiPS cells in B6 mice

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Transcription profiling of human embryonic stem cell derived tumors (teratomas)

Project description:Gene expression analysis of human embryonic stem cell derived tumors (teratomas). Experiment Overall Design: Undifferentiated HESCs were injected into the testis or under the kidney capsule of SCID-NOD mice and were let to grow for one month prior to tumor harvesting.

2008-11-21 | E-GEOD-13586 | biostudies-arrayexpress

The Effect of liver regeneration on hESCs transplanted into SCID mice

Project description:A source of functioning hepatocytes for liver cell transplantation and liver support is in need. hESCs , when transplanted, generally form teratomas. We studied capacity of hESCs to differentiate to hepatocyte like cells under the effect of in vivo liver regeneration. In SCID-Beige mice hepatocyte replication peaked 48 hours after CCl4 injection; 24 hours earlier 106 hESCs or EBs at different stages of differentiation were transplanted into the spleen. Comparisons were made to teratomas formed in the hind limb of untreated animals. RT-PCR and gene microarray were used for liver and human specific markers. Immunohistochemistry to AFP,AAT, ALB, HEP-PAR I AND CK-18,19 were performed. EBs formed a single large teratoma in the spleen and small teratomas in the liver. Expression of PCR- identified liver specific markers was greater in the spleen than in the liver. Adult hepatocyte specific markers were expressed in the hind limb teratoma excised after 7 weeks. When late EBs were transplanted before CCl4 exposure, no teratomas formed. Rather, an abundance of probably undifferentiated ectodermal origin cells presented. In this descriptive study, transplanted early human EBs formed teratomas that differed in size and molecular markers. Within teratomas, the degree of maturation into hepatocytes correlated better with the time duration in vivo than with growth stimulation. Late EBs formed non differentiated ectodermal cells only in a regenerative microenvironment.

2011-12-31 | GSE31136 | GEO

The Effect of liver regeneration on hESCs transplanted into SCID mice

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Arrayexpression analysis of Evi-overexpressing teratomas

Project description:Canonical and non-canonical Wnt signaling play key roles during development and tumorigenesis. In this study we compared gene expression in teratomas grown from mouse embryonic stem cells that overexpress Evi/Wls and teratomas from normal embryonic stem cells cells.

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Patient-Derived Liver on Chips

Project description:Patient-Derived Liver on Chips

| PRJNA779387 | ENA

Gene expression analysis of HESC derived teratomas

Project description:Gene expression analysis of human embryonic stem cell derived tumors (teratomas).

2008-11-14 | GSE13586 | GEO

Homo sapiens

Project description:Gene expression data from teratomas formed by human iPSCs (chiPS) in SCID (Severe combined immunodeficiency) mice and humanized SCID mice (HuSCID)

| PRJNA167182 | ENA

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