Dataset Information
Transcriptional profiling of ptc6 and ptc1ptc6 mutant yeast cells and the effects of Rapamycin
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Yeast_ALL DNA chip
SUBMITTER: 
Antonio Casamayor
PROVIDER: GSE38260 | GEO | 2013-04-19
SECONDARY ACCESSION(S): PRJNA167501 GSE38256S-EPMC3660562 GSE38244
REPOSITORIES: GEO
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| GSE38260_RAW.tar | Raw | |||
| filelist.txt | Txt |
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Publications
Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.
PloS one 20130521 5
Ptc6 is one of the seven components (Ptc1-Ptc7) of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li(+). Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenoty ...[more]
