Genomics

Dataset Information

20

Transcriptional profiling of ptc6 and ptc1ptc6 mutant yeast cells and the effects of Rapamycin


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Yeast_ALL DNA chip

SUBMITTER: Antonio Casamayor  

PROVIDER: GSE38260 | GEO | 2013-04-19

SECONDARY ACCESSION(S): PRJNA167501 GSE38256S-EPMC3660562 GSE38244

REPOSITORIES: GEO

Dataset's files

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Publications

Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.

González Asier A   Casado Carlos C   Ariño Joaquín J   Casamayor Antonio A  

PloS one 20130521 5


Ptc6 is one of the seven components (Ptc1-Ptc7) of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li(+). Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenoty  ...[more]

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