Transcriptomics,Genomics

Dataset Information

49

MicroRNAs and their target proteins are associated with characteristics of estrogen receptor-positive breast cancer (miRNA data)


ABSTRACT: Recent analyses have identified heterogeneity in estrogen receptor (ER)-positive breast cancer. There are so-called luminal A and luminal B subtypes, and the characteristics, such as response to endocrine therapy and chemotherapy and prognosis, are different in these two subtypes of breast cancer. In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissues were compared between highly and incompletely endocrine responsive tumors by miRNA and mRNA microarrays. Unsupervised hierarchical clustering analyses revealed distinct expression patterns of miRNAs and mRNAs in these two groups. We identified one miRNA that was downregulated in highly endocrine responsive tumors and 8 miRNAs that were downregulated in incompletely endocrine responsive tumors, and target genes of these miRNAs were predicted using TargetScan and MiRanda. Protein expression patterns of the predicted target genes and the genes that were identified by mRNA expression profiling were analyzed in ER-positive breast cancer samples by immunohistochemistry. We identified a novel protein that might be associated with characteristics of ER-positive breast cancer. Overall design: Expression profiles of microRNAs in highly and incompletely endocrine responsive tumors using 8 (4 tumors in each group) frozen human breast cancer tissues.

INSTRUMENT(S): 3D-Gene Human miRNA V14_1.0.1

SUBMITTER: Satoshi Kondo  

PROVIDER: GSE38278 | GEO | 2013-03-04

SECONDARY ACCESSION(S): PRJNA167591

REPOSITORIES: GEO

altmetric image

Publications

miR-1290 and its potential targets are associated with characteristics of estrogen receptor α-positive breast cancer.

Endo Yumi Y   Toyama Tatsuya T   Takahashi Satoru S   Yoshimoto Nobuyasu N   Iwasa Mai M   Asano Tomoko T   Fujii Yoshitaka Y   Yamashita Hiroko H  

Endocrine-related cancer 20130218 1


Recent analyses have identified heterogeneity in estrogen receptor α (ERα)-positive breast cancer. Subtypes called luminal A and luminal B have been identified, and the tumor characteristics, such as response to endocrine therapy and prognosis, are different in these subtypes. However, little is known about how the biological characteristics of ER-positive breast cancer are determined. In this study, expression profiles of microRNAs (miRNAs) and mRNAs in ER-positive breast cancer tissue were com  ...[more]

Similar Datasets

| GSE38279 | GEO
2012-03-09 | E-GEOD-31003 | ArrayExpress
| GSE53300 | GEO
2008-09-27 | E-TABM-563 | ArrayExpress
2018-10-03 | GSE104986 | GEO
2012-03-20 | E-GEOD-32646 | ArrayExpress
2011-07-08 | E-GEOD-22219 | ArrayExpress
2011-07-08 | E-GEOD-22216 | ArrayExpress
2005-12-01 | GSE2740 | GEO
2013-03-05 | E-GEOD-44408 | ArrayExpress