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Global expression profiling of treatment-induced senescence in mouse Emu-myc B-cell lymphomas

ABSTRACT: Therapy-induced senescence (TIS) is a DNA damage-triggered irreversible cell-cycle block that terminates further expansion of (pre-)malignant lesions. Utilizing the Eµ-myc transgenic mouse lymphoma model (apoptosis protected by retroviral Bcl2-overexpression), we sought to elucidate the biological properties, long-term fate of senescent tumor cells and their impact on the microenvironment. We used global gene expression profiling by microarrays to gain insight into the molecular program underlying the treatment-induced senescence in Emu-myc transgenic B-cell lymphomas (apoptosis protected by Bcl2 overexpression), which robustly enter senescence in response to DNA-damaging anticancer agents such as Adriamycin (ADR).

ORGANISM(S): Mus musculus

PROVIDER: GSE38285 | GEO | 2020/12/31

REPOSITORIES: GEO

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Expression data from Adriamycin-treated Emu-myc; Suv39h1-/- B-cell lymphoma

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