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Transcriptional response to tetanus vaccination in porcine PBMCs

ABSTRACT: Three groups of German Landrace piglets were vaccinated with tetanus toxoid. Transcriptome profiles of PBMC were analysed from blood samples taken 0, 2, 4, 8, 24 and 75 hours after a first vaccination and 0, 2, 4, 8, 24 and 75 hours as well as 14 d after a second vaccination on day 14.

ORGANISM(S): Sus scrofa

PROVIDER: GSE38602 | GEO | 2012/12/31

SECONDARY ACCESSION(S): PRJNA168206

REPOSITORIES: GEO

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Transcriptional response to tetanus vaccination in porcine PBMCs

Project description:Three groups of German Landrace piglets were vaccinated with tetanus toxoid. Transcriptome profiles of PBMC were analysed from blood samples taken 0, 2, 4, 8, 24 and 75 hours after a first vaccination and 0, 2, 4, 8, 24 and 75 hours as well as 14 d after a second vaccination on day 14. pair wise comparison of 0 hours to the respective time points after each vaccination

2012-12-31 | E-GEOD-38602 | biostudies-arrayexpress

Allergen-induced activation of NK cell genes represents an early life immune response in development of allergic asthma

Project description:Peripheral blood samples from children enrolled in the URECA cohort were collected at age 2. In short, at each URECA research center, within 16 hours of blood collection, mononuclear cells were separated and incubated (48 hours, 37C, 5% CO2) in the presence of German cockroach extract (10mg/mL; CR), dust mite extract (Dermatophagoides pteronyssinus, 10mg/mL; DM), tetanus toxoid (5mg/mL; TT), or medium alone (NS).

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Proteomic identification of anti-tetanus toxoid antibodies from human serum (HD1)

Project description:Proteomic identification and characterization of antibodies comprising the serological response to antigen can provide unique insight into the functional dynamics of adaptive immunity. We have developed a novel method to overcome the technical challenges which previously limited the direct analysis of immunoglobulin proteins in serum, as demonstrated by the identification of human anti-tetanus toxoid (TT) immunoglobulin G (IgG) proteins following booster vaccination. We analyzed the serum IgG repertoire across four time-points corresponding to pre-vaccination, 7 days, 3 months, and 9 months post vaccination. Antigen-specific antibodies were affinity purified against immobilized TT protein and sequenced by bottom-up nanoLC-MS/MS. Interpretation of mass spectra required a custom reference database of IgG heavy and light chain variable sequences determined by NextGen RNA sequencing of the donor's circulating plasmablasts and memory B cells following booster vaccination.

2014-04-24 | PXD000917 | Pride

Transcriptional response to tetanus toxoid in pigs with divergent humoral and lean growth performance

Project description:In vivo microarray study of transcriptional changes in porcine peripheral blood mononuclear cells (PBMCs) during the immune response to tetanus vaccination

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Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer

Project description:RATIONALE: Vaccines may make the body build an immune response to kill tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Tetanus toxoid may make tumor cells more sensitive to chemotherapy and vaccine therapy. PURPOSE: Randomized phase II trial to study the effectiveness of chemotherapy and vaccine therapy with or without tetanus toxoid compared with chemotherapy alone in treating patients who have metastatic colorectal cancer.

| 2006963 | ecrin-mdr-crc

Transcriptional response to tetanus toxoid in pigs with divergent temperament (High-Reactive vs. Low-Reactive) [day 28]

Project description:in vivo microarray study of transcriptional changes in porcine peripheral blood mononuclear cells (PBMCs) during the immune response to tetanus vaccination.

2014-12-01 | GSE55415 | GEO

Transcriptional response to tetanus toxoid in pigs with divergent temperament (High-Reactive vs. Low-Reactive) [day 14]

Project description:in vivo microarray study of transcriptional changes in porcine peripheral blood mononuclear cells (PBMCs) during the immune response to tetanus vaccination.

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Transcriptional response to tetanus toxoid in pigs with divergent temperament (High-Reactive vs. Low-Reactive) [day 0]

Project description:in vivo microarray study of transcriptional changes in porcine peripheral blood mononuclear cells (PBMCs) during the immune response to tetanus vaccination.

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Transcriptional response to tetanus toxoid in pigs with divergent temperament (High-Reactive vs. Low-Reactive) [day 140]

Project description:in vivo microarray study of transcriptional changes in porcine peripheral blood mononuclear cells (PBMCs) during the immune response to tetanus vaccination.

2014-12-01 | GSE55417 | GEO

Deciphering transcriptome profiles of porcine PBMCs in response to porcine reproductive and respiratory syndrome virus vaccine

Project description:In vivo microarray study of global gene expression changes in peripheral blood mononuclear cells (PBMCs) of German Landrace pigs during the innate immune response to porcine reproductive and respiratory syndrome virus vaccination.

2017-02-14 | GSE78254 | GEO

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