Gene expression profiling of CD4+myelin basic protein specific T cells

ABSTRACT: CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. However how these T cells become able to transgress the blood brain barrier is not CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. Here a gene expression profile of the pathogenic T cells in different functional states was performed. These studies were performed in a classical model of multiple sclerosis, experimental autoimmune encephalomyelitis in Lewis rats induced by transfer of CD4+myelin basic protein specific T cells. We found that on their way to the CNS T cells fundamentally reprogram their gene expression profile, by down-regulating their activation program and up-regulating cell locomotion molecules.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE38645 | GEO | 2012/08/23

SECONDARY ACCESSION(S): PRJNA168304

REPOSITORIES: GEO