Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of transgenic human IL8 on gene expression in mouse colon cancer tumors

ABSTRACT: mRNA expression in colon cancer tumores of CBA/C57BL/6 transgenic mice bearing a BAC which contains the human IL8 gene and promoter was compared to that of CBA/C57BL/6 controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE39273 | GEO | 2013/01/11

SECONDARY ACCESSION(S): PRJNA170448

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Effect of transgenic human IL8 on gene expression in mouse colon cancer tumors

Project description:mRNA expression in colon cancer tumores of CBA/C57BL/6 transgenic mice bearing a BAC which contains the human IL8 gene and promoter was compared to that of CBA/C57BL/6 controls. A. CBA/C57BL/6 mice controls (n=3) B. human IL8 transgenic CBA/C57BL/6 mice (n=3).

2013-01-11 | E-GEOD-39273 | biostudies-arrayexpress

Expression data from BAC transgenic mice overexpressing Glo1

Project description:We generated mice with a transgenic BAC on a B6 background. The BAC contains Glo1, and the transgenic mice were found to overexpress Glo1. We performed a microarray on whole-brain RNA of adult mice to identify differentially expressed genes resulting from Glo1 overexpression.

2012-03-27 | GSE36819 | GEO

Expression data from BAC transgenic mice overexpressing Glo1

2012-03-26 | E-GEOD-36819 | biostudies-arrayexpress

High gene expression of IL8 in peripheral blood mononuclear cells from bladder cancer patients is associated with nonresponders to atezolizumab

Project description:Elevated plasma interleukin-8 (IL8) has been associated with poor outcome to immune checkpoint blockade. Here we performed single cell RNAseq with peripheral blood mononuclear cells (PBMCs) of patients treated with atezolizumab (anti-PD-L1 mAb) from bladder cancer from a Phase II trial IMvigor210. We found that high IL8 gene expression is enriched in nonresponders to atezolizumab

2020-02-14 | GSE145281 | GEO

Gene profiling in CBA and BL/6 bone marrow derived dendritic cells (BMDC)

2014-02-25 | GSE55307 | GEO

Mouse Inbred Strain Variation Muscle

Project description:Variation in gene expression profiles was determined between mouse inbred strains in hindlimb muscle tissue. Strains under investigation were: C57Bl/6, C57Bl/10, CBA, DBA2, and BALB/c. Keywords: other

2003-12-10 | GSE662 | GEO

Paracrine Secretion of IL8 by Breast Cancer Stem Cells Promotes Therapeutic Resistance and Metastasis

Project description:Breast cancer stem cells (CSCs) play pivotal roles in cancer therapeutic failure and metastasis. However, it remains indeterminate how CSCs determine the progression of the bulk cancer cell population. Using a co-culture system in vitro and a co-implantation system in vivo, it is demonstrated herein that the breast cancer stem cell (BCSC) secretome rendered the bulk cancer cell population resistant to anti-estrogen and CDK4/6 inhibitor therapy; as well as increased the metastatic burden attributable to bulk cancer cells. Screening of BCSC secretome identified IL8 as a pivotal factor that potentiated ERα activity, endowed tamoxifen resistance and enhanced metastatic burden by regulation of bulk cancer cell behavior. Pharmacological inhibition of IL8 increased the efficacy of fulvestrant and/or palbociclib by reversing tamoxifen resistance and abrogated metastatic burden. Hence, this study has delineated the mechanism by which BCSCs determine the therapeutic response and metastatic of bulk cancer cells; and thereby suggests novel therapeutic strategies to ameliorate breast cancer outcomes.

2022-12-30 | GSE220295 | GEO

Mouse Inbred Strain Variation Muscle

2003-12-09 | E-GEOD-662 | biostudies-arrayexpress

Gene profiling in CBA and BL/6 bone marrow derived dendritic cells (BMDC)

Project description:Analysis of baseline gene expression in bone marrow derived dendritic cells (BMDC) from female CBA/J (CBA) and C57BL/6 (BL/6) mice. Results provide insight into strain-dependent differences in gene expression. CBA and BL/6 BMDCs prepared from individual mice were plated in replicate at 1x10^6 cells/ml in 48-well tissue culture plates (BD Falcon). Replicates were pooled after 4hr and total RNA was obtained by TrizolM-BM-. (Invitrogen) extraction according to the manufacturerM-bM-^@M-^Ys instructions.

2014-02-25 | E-GEOD-55307 | biostudies-arrayexpress

Transcriptional response to vanoxerine in vivo treatments in MC38 colorectal tumors

Project description:Murine colorectal cancer MC38 cells were injected in the flank of C57BL/6 mice to form tumor grafts over 7 days. Tumor-bearing mice were treated with daily injections of vanoxerine (25mg/kg) or vehichle control (saline) over 10 consecutive days. Tumors were excised and RNA sequencing profiling was performed on both experimental condition.

2022-07-13 | GSE207032 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data