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Evaluation of microRNAs in urine samples as indicators of prostate cancer occurrence

ABSTRACT: miRNAs have been proven to be very useful biomarkers, readily detectable in body fluids, particularly urine may be a valuable source to identify changes in miRNA levels that contribute to better differentiate prostate cancer (PCa) from benign prostate hyperplasia (BPH) cases. In order to characterize microRNA expression in urine samples from PCa, we analyzed expression of 376 microRNAs in 9 samples of PCa and 9 of BPH. The Normalized Ct values were compared between PCa and BPH. Statistical comparisons were made using Mann-Whitney U test, considering two different distributions. We found statiscally differences n expression for 21 miRNAs (Fold change >2 and P value<0.05).

ORGANISM(S): Homo sapiens

PROVIDER: GSE39314 | GEO | 2012/07/12

SECONDARY ACCESSION(S): PRJNA170542

REPOSITORIES: GEO

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Evaluation of microRNAs in urine samples as indicators of prostate cancer occurrence

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