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Gene Expression Changes Associated With TLR2 Mediated Inhibition of Allergen Specific TH2 Response In Vitro

ABSTRACT: Investigation of the gene expression changes associated with TLR2 adjuvant (lipoteichoic acid; LTA) inhibition of allergic TH2 responses in peripheral blood mononuclear cell cultures (derived from house dust mite allergic individuals) stimulated with house dust mite extract.

ORGANISM(S): Homo sapiens

PROVIDER: GSE39476 | GEO | 2012/07/19

SECONDARY ACCESSION(S): PRJNA170942

REPOSITORIES: GEO

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Gene Expression Changes Associated With TLR2 Mediated Inhibition of Allergen Specific TH2 Response In Vitro

Project description:Investigation of the gene expression changes associated with TLR2 adjuvant (lipoteichoic acid; LTA) inhibition of allergic TH2 responses in peripheral blood mononuclear cell cultures (derived from house dust mite allergic individuals) stimulated with house dust mite extract. Pooled samples from 5 individuals were analysed by microarray; qPCR validation was carried out in a larger cohort of 23 individuals.

2012-07-18 | E-GEOD-39476 | biostudies-arrayexpress

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Project description:We are examining the consequences of activating mutations in PI3K-delta in Th1 vs. Th2 differentiation. Using the house dust mite (HDM) model of allergic airway inflammation, which drives potent Th2 responses in vivo, we have found mice expressing hyper-activated PI3K-delta show impaired Th2 differentiation and instead favor Th1 cell differentiation. We would like to further investigate this aberrant CD4 differentiation profile using scRNA-seq to characterize PI3K-delta regulated aspects of type II immunity.

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Collaborative Cross founder strain lung miRNA expression after allergen challenge

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Genome-wide expression profiling of B Lymphocytes reveals IL4R increase in allergic asthma

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Collaborative Cross founder strain lung miRNA expression after allergen challenge

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