Young and old HSCs from WT and Lnk-/- mice

ABSTRACT: The adaptor protein Lnk is an important negative regulator of HSC homeostasis and self-renewal. This study aims to investigate the role of Lnk in HSC aging. Here we performed expression profiling of bone marrow CD150+CD48-LSK LT-HSCs from young and old WT and Lnk-/- mice. Results identify select Lnk-mediated pathways with potential involvement in HSC self-renewal and aging.

ORGANISM(S): Mus musculus

PROVIDER: GSE39553 | GEO | 2012/10/03

SECONDARY ACCESSION(S): PRJNA171115

REPOSITORIES: GEO