Genomics

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A transcription factor based mechanism for mouse heterochromatin formation


ABSTRACT: We identify Pax3 and Pax9 transcription factors (TFs) as important regulators of mouse heterochromatin. Simultaneous depletion of these factors results in loss of H3K9me3 from Major Satellite repeats and dramatic transcript overexpression. H3K9me3 enrichment at intergenic major satellite repeats is only present if these sequences retain intact Pax and other TF binding sites.

ORGANISM(S): Mus musculus

PROVIDER: GSE40086 | GEO | 2012/09/16

SECONDARY ACCESSION(S): PRJNA172759

REPOSITORIES: GEO

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