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The cistrome of NKX3.1 in LNCaP prostate cancer cells

ABSTRACT: Here we report the genome-wide set of factors bound by NKX3.1 or control IgG in human prostate cancer cells (LNCaP).

ORGANISM(S): Homo sapiens

PROVIDER: GSE40269 | GEO | 2013/08/21

SECONDARY ACCESSION(S): PRJNA173399

REPOSITORIES: GEO

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The cistrome of NKX3.1 in LNCaP prostate cancer cells

Project description:Here we report the genome-wide set of factors bound by NKX3.1 or control IgG in human prostate cancer cells (LNCaP). Examination of NKX3.1 binding in LNCaP prostate cancer cells

2013-08-21 | E-GEOD-40269 | biostudies-arrayexpress

NKX3.1 localization to mitochondria suppresses prostate cancer initiation (Mouse 4M Prostate RNASeq)

Project description:The NKX3.1 homeobox gene functions in mitochondria to regulate oxidative stress To investigate the role of NKX3.1 in regulation of oxidative stress, we employed transcriptome analysis of mouse prostate ( from 4 month old Nkx3.1+/+ and Nkx3.1-/- mice treated with paraquat), and human prostate cells ( RWPE1 cells engineered with empty vector (altered pTRIPZ), NKX3.1 wild type over-expression, and NKX3.1 (R52C) over-expression treated with paraquat). Mouse tissue or human cells were snap frozen for subsequent molecular analysis.

2021-04-13 | GSE115337 | GEO

NKX3.1 localization to mitochondria suppresses prostate cancer initiation (Human RWPE1 RNASeq)

2021-04-13 | GSE115335 | GEO

Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation

Project description:To investigate the role of NKX3.1 in prostate differentiation, we employed transcriptome analysis of mouse seminal vesicle (from 15-month-old Nkx3.1+/+ mice); mouse prostate (from 4-month-old Nkx3.1+/+ and Nkx3.1-/- mice); human prostate cells (RWPE1 cells engineered with empty vector (altered pTRIPZ), NKX3.1 wild type over-expression, and NKX3.1 (T164A) mutant over-expression); and tissue recombinants (generated from combining engineered mouse epithelial cells (seminal vesicle epithelial cells or prostate epithelial cells from 2-month-old mice) and rat UGS mesenchymal cells). Mouse tissue or human cells were snap frozen for subsequent molecular analysis. This SuperSeries is composed of the SubSeries listed below.

2016-06-24 | GSE81440 | GEO

Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation

2016-06-24 | E-GEOD-81440 | biostudies-arrayexpress

Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_4M-Prostate_RNA-Seq)

Project description:Analysis of transcriptome of prostate tissue from 4-month-old Nkx3.1 +/+ and Nkx3.1 -/- mice. Total RNA obtained from prostate tissues from 4-month-old Nkx3.1 +/+ and Nkx3.1 -/- mice. Prostate tissues were harvested and processed for RNA isolation and transcriptome analysis using the MagMAX RNA isolation kit (Ambion).

2016-06-24 | E-GEOD-81424 | biostudies-arrayexpress

Identification of an NKX3.1-G9a-UTY regulatory network that controls prostate differentiation (Mouse_4M-Prostate_RNA-Seq)

Project description:Analysis of transcriptome of prostate tissue from 4-month-old Nkx3.1 +/+ and Nkx3.1 -/- mice.

2016-06-24 | GSE81424 | GEO

The effects of NAC on gene expression in Nkx3.1-/- mouse prostate

Project description:We tested the effects of the antioxidant NAC (N-Acetyl-Cysteine) on gene expression in Nkx3.1-deficient mouse prostate.

2012-10-23 | GSE40352 | GEO

Systems analysis of the prostate tumor suppressor NKX3.1 substantiates roles in DNA repair and a transcriptional program that drives luminal cell differentiation

Project description:NKX3.1 is an androgen-regulated, prostate-specific gene located on chromosome 8p21, a region frequently undergoing allelic loss in human prostate cancer. Mice deficient in NKX3.1 show signs of epithelial de-differentiation and develop dysplasia and prostatic intraepithelial neoplasia (PIN) that progresses to overt prostate cancer when combined with deletions of additional tumor suppressors such as PTEN or p27Kip1. Although NKX3.1 displays the typical features of an NK class homeobox transcription factor, mechanisms of NKX3.1-mediated tumor suppression remain insufficiently understood because neither the transcriptional program governed by NKX3.1 nor its interacting proteins have been comprehensively revealed.

2013-12-25 | GSE47030 | GEO

The effects of NAC on gene expression in Nkx3.1-/- mouse prostate

Project description:We tested the effects of the antioxidant NAC (N-Acetyl-Cysteine) on gene expression in Nkx3.1-deficient mouse prostate. Mice that were homozygous null for Nkx3.1 were given NAC or plain water ad libidum for 13 weeks after weaning. Prostates were collected, RNA was harvested and reverse transcribed, and cDNA was hybridized to Affy Mouse Gene 1.0 ST microarrays.

2012-10-23 | E-GEOD-40352 | biostudies-arrayexpress

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