Differentially expressed genes during disuse atrophy.

ABSTRACT: To identify atrophy genes directly targeted by Bcl-3 transactivator at a genome wide level, we performed whole transcript expression array and ChIP-seq for muscles from weight bearing or 5-day hind limb unloaded mice. Genes that showed increased expression with unloading and a Bcl-3 peak in the promoter (from ChIP-seq data) were considered as Bcl-3 direct targets during disuse atrophy. Using ChIP array, we identified 241 direct targets for Bcl-3. Our data describe Bcl-3 as a global regulator both of the proteolysis and the change in energy metabolism that are essential components of muscle atrophy due to disuse.

ORGANISM(S): Mus musculus

PROVIDER: GSE40578 | GEO | 2012/11/10

SECONDARY ACCESSION(S): PRJNA174343

REPOSITORIES: GEO