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Expression profile of human HepG2 cells treated with PADMA28 ethanolic extracts or EtOH solvent control

ABSTRACT: The aim of this study was to analyze the influence of PADMA28 ethanolic extracts on HepG2 gene expression. PADMA28 (Swissmedic Nr. 58436) is an Indo-Tibetan polyherbal preparation used for the treatment of symptoms associated with circulatory disorders.

ORGANISM(S): Homo sapiens

PROVIDER: GSE40580 | GEO | 2012/10/01

SECONDARY ACCESSION(S): PRJNA174340

REPOSITORIES: GEO

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Expression profile of human HepG2 cells treated with PADMA28 ethanolic extracts or EtOH solvent control

Project description:The aim of this study was to analyze the influence of PADMA28 ethanolic extracts on HepG2 gene expression. PADMA28 (Swissmedic Nr. 58436) is an Indo-Tibetan polyherbal preparation used for the treatment of symptoms associated with circulatory disorders. Triplicate cultures of HepG2 cells were treated with either PADMA28 or EtOH solvent control for 18 hours. After cell harvest, the triplicates were pooled and total RNA was extracted. The RNA was analyzed using Affymetrix Human Genome U133 Plus 2.0 microarrays (one array per treatment).

2012-10-01 | E-GEOD-40580 | biostudies-arrayexpress

Ethanolic extracts of unlabeled and 13C labeled yeast and mixtures thereof

Project description:Ethanolic extracts of unlabeled and fully 13C labeled yeast (Pichia pastoris) and mixtures thereof were measured on HILIC and C18 (Dual injection system with HILIC eluting until 15 min and RPC after 15 min).

2022-03-08 | MSV000089018 | MassIVE

Transcriptome profiling of HeLa TAF7 (WT) cytoplasmic extracts

Project description:We perform RNA-Seq to analyze gene expression profiles in HeLa TAF7 (WT) cytoplasmic extracts, which are the inputs of RIP-Seq and PAR-CLIP.

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The effect of plant extracts on human macrophage activation

Project description:Members of the Caryophyllaceae Juss. family possess anabolic, adaptogenic, radioprotective, antitumoral and hemorheological properties and have been used in medical practice for the treatment of various inflammatory disorders. Macrophages are key immune cells that coordinate the inflammatory reaction. To identify the effects of Silene sendtneri and Silene roemeri on macrophage activation, primary human macrophages were cultured with extracts of these plants .We used microarrays to determine the global expression pattern induced by the extracts in macrophages.

2020-10-20 | GSE99447 | GEO

Soil DNA extracts from greenhouse study

Project description:Soil DNA extracts from greenhouse study Raw sequence reads

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Polyubiquitination analysis upon GSK3 inhibition in HeLa cell extracts

Project description:HeLa cell extracts with or without GSK3 enzyme inhibition were assayed using protein microarrays in order to detect GSK3-dependent changes in protein polyubiquitination.

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Alterations in the Transcriptional Profile of the Liver Tissue and the Therapeutic Effects of Propolis Extracts in Alcohol-induced Steatosis in Rats

Project description:Gene expression Array analysis has been an effective technique for exploring treatment-associated transcriptional changes in tissues. The main goal of this study is to explore the expression changes of transcripts in the liver tissue of rats which were treated with the ethanolic extraction of propolis (EEP) as well as alcohol. We aim to find a subset of genes which responded to the treatment of EEP and may be useful candidate genes in explaining the protective effects of EEP on fatty liver.

2017-06-20 | GSE100173 | GEO

Effect of Rosa roxburghii fruit extracts to gene expression of mesenchymal stem cells

Project description:Here we found Rosa roxburghii fruit extracts effectively increase TERT expression and telomerase activity in cultured human mesenchymal stem cells. Both Rosa roxburghii fruit extracts by freeze drying and spray drying methods increase the activity of telomerase. Rosa roxburghii fruit freeze drying extracts is able to reduce reactive oxygen species levels, enhance SOD activity and resistance to oxidative stress, and reduce DNA damage caused by oxidative stress or radiation. Rosa roxburghii fruit extracts promoted cell proliferation, improved senescent cell morphology, delayed replicative cellular senescence, attenuated cell cycle supressors and alleviated the senescence-associated secretory phenotype. Transcriptome and metabolic profilings found that Rosa roxburghii fruit extract promote cell proliferation and DNA repair pathways, decreased triglycerides as well. Overall, we provided a theoretical basis for the application of Rosa roxburghii fruit as an anti-aging natural product.

2024-04-01 | GSE261987 | GEO

Yarrow and marigold extracts and their effect in pancreatic cancer cells [MIL]

Project description:determine the molecular effect of yarrow and marigold supercritical extracts in gene expression of pancreatic cancer cells (MIA PaCa-2)

2018-12-19 | GSE124043 | GEO

Yarrow and marigold extracts and their effect in pancreatic cancer cells [CAL]

Project description:determine the molecular effect of yarrow and marigold supercritical extracts in gene expression of pancreatic cancer cells (MIA PaCa-2)

2018-12-19 | GSE124042 | GEO

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