Genomics

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Expression analysis of C. elegans genes kin-1 and crh-1 mutant


ABSTRACT: Investigation of whole genome gene expression level changes in C. elegans genes kin-1 and crh-1 mutant, compared to the wild-type strain. NimbleScan software’s implementation of RMA offers quantile normalization and background correction. There are three steps of RMA: Firstly, background subtraction was performed using a local background estimator. Secondly, quantile normalization (Bioinformatics 2003; 19:185) at probe level was done to make the expression distributions the same for all arrays. Last, probe set summarization was performed using Robust Multichip Average (RMA) algorithm as described by Irizarry, et al. (Nucleic Acids Res. 2003; 31:e15 and Biostatistics 2003; 4:249).

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE40809 | GEO | 2012/09/13

SECONDARY ACCESSION(S): PRJNA175021

REPOSITORIES: GEO

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