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SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

ABSTRACT: Comparing the host response of C57BL/6J mice to KEPI (ppp1r14c) knockouts in the same strain of mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE40827 | GEO | 2012/09/13

SECONDARY ACCESSION(S): PRJNA175055

REPOSITORIES: GEO

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SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice.

2012-09-13 | GSE40840 | GEO

SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1b knockouts in the same strain of mice.

2012-09-13 | GSE40824 | GEO

SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

Project description:Comparing the host response of C57BL/6J mice to KEPI (ppp1r14c) knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or KEPI (ppp1r14c) knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40827 | biostudies-arrayexpress

SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40840 | biostudies-arrayexpress

SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40824 | biostudies-arrayexpress

RNA sequencing of C57BL/6J mice, heterozygous for knockout of Hnrnph1 gene, as well as C57BL/6J mice controls

Project description:Previous studies of congenic lines of C57BL/6J-DBA/2J mice compared to C57BL/6 mice revealed a 0.23 QTL for sensitivity to methamphetamine on chromosome 11, which contains two protein coding genes, Rufy1 and Hnrnph1. Subsequent transcription activator-like effector nucleases (TALENs)-mediated introduction of frameshift deletions in the first coding exon of one copy of Hnrnph1 of C57BL/6J mice, revealed comparable association to phenotype. Analysis of the transcriptome and splicesome between these Hnrnph1 heterozygous knockouts and C57BL/6J mice revealed genome-wide differentially expression and exon usage of more than 1000 genes in either.

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Platelet proteomic analysis of exercising and standard-housed aged C57BL/6J mice

Project description:Platelets were isolated from standard-housed and exercising (4 days and 28 days) 18-month-old C57BL/6J mice and mass spectrometry performed. This analysis revealed differential proteomic signatures between platelets from exercsising and standard-housed mice.

2023-08-18 | PXD041701 | Pride

C57BL/6J

Project description:Faecal microbiota composition across different C57BL/6J inbred mice generations

| PRJNA335681 | ENA

Genetic Determinants for Susceptibility to Staphylococcus aureus Infection in A/J and C57BL/6J

Project description:Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome substitution strains (CSS), we found that factors on chromosomes (chr) 8, 11, and 18 are responsible for susceptibility to S. aureus sepsis in A/J mice. F1 mice from C57BL/6J X CSS8 cross (C8A) and C57BL/6J X CSS18 (C18A) were also susceptible to S. aureus (median survival < 48 h), whereas F1 mice from C57BL/6J X CSS11 cross (C11A) were resistant (median survival > 120 h) to S. aureus. Bacterial loads in the kidney were consistent with F1 median survivals, with higher bacterial counts in susceptible mice. No sexlinked associations with susceptibility were noted in F1 intercrosses. Using whole genome transcription profiling, we identified a total of 192 genes on chromosomes 8, 11, and 18 which are differentially expressed between A/J and C57BL/6J in the setting of S. aureus infection. Of these, 28 genes had Gene Ontology annotations indicating a potential immune response function. These 28 genes are associated with susceptibility to S. aureus in A/J mice, and are potential determinants of susceptibility to S. aureus infection in humans.

2010-08-01 | GSE19668 | GEO

Genetic Determinants for Susceptibility to Staphylococcus aureus Infection in A/J and C57BL/6J

2010-08-01 | E-GEOD-19668 | biostudies-arrayexpress

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