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SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

ABSTRACT: Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE40840 | GEO | 2012/09/13

SECONDARY ACCESSION(S): PRJNA175064

REPOSITORIES: GEO

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SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40840 | biostudies-arrayexpress

SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40824 | biostudies-arrayexpress

SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

Project description:Comparing the host response of C57BL/6J mice to KEPI (ppp1r14c) knockouts in the same strain of mice.

2012-09-13 | GSE40827 | GEO

SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

Project description:Comparing the host response of C57BL/6J mice to KEPI (ppp1r14c) knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or KEPI (ppp1r14c) knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

2012-09-13 | E-GEOD-40827 | biostudies-arrayexpress

SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1b knockouts in the same strain of mice.

2012-09-13 | GSE40824 | GEO

Mus musculus

Project description:SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

| PRJNA175064 | ENA

RNA sequencing of C57BL/6J mice, heterozygous for knockout of Hnrnph1 gene, as well as C57BL/6J mice controls

Project description:Previous studies of congenic lines of C57BL/6J-DBA/2J mice compared to C57BL/6 mice revealed a 0.23 QTL for sensitivity to methamphetamine on chromosome 11, which contains two protein coding genes, Rufy1 and Hnrnph1. Subsequent transcription activator-like effector nucleases (TALENs)-mediated introduction of frameshift deletions in the first coding exon of one copy of Hnrnph1 of C57BL/6J mice, revealed comparable association to phenotype. Analysis of the transcriptome and splicesome between these Hnrnph1 heterozygous knockouts and C57BL/6J mice revealed genome-wide differentially expression and exon usage of more than 1000 genes in either.

2017-02-01 | GSE76929 | GEO

E-GEOD-40840

Project description:SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

2020-03-31 | E-GEOD-40840 | ExpressionAtlas

C57BL/6J

Project description:Faecal microbiota composition across different C57BL/6J inbred mice generations

| PRJNA335681 | ENA

C57BL/6J mice B and T cell LC-MSMS study

Project description:Proteome isolated from C57BL/6J mouse B and T cells are evluated for the presence of novel open reading frame products (nORFs). Translation products encoded by non canonical or novel open reading frame (ORF) genomic regions are generally considered too small to play any significant biological role, and dismissed as inconsequential. We conduct a systematic study of novel ORFs to gain new insights into normal biological and disease processes.

2021-09-09 | PXD022099 | Pride

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