Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA175134PRJNA175136PRJNA175135E-GEOD-40845E-GEOD-40846
INSTRUMENT(S): Illumina Genome Analyzer IIx (Mycobacterium tuberculosis)
SUBMITTER: Swapna Uplekar
PROVIDER: GSE40862 | GEO | 2012-12-01
SECONDARY ACCESSION(S): PRJNA175136 GSE40845 GSE40846
REPOSITORIES: GEO
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Uplekar Swapna S Rougemont Jacques J Cole Stewart T ST Sala Claudia C
Nucleic acids research 20121207 2
To construct a regulatory map of the genome of the human pathogen, Mycobacterium tuberculosis, we applied two complementary high-resolution approaches: strand-specific RNA-seq, to survey the global transcriptome, and ChIP-seq, to monitor the genome-wide dynamics of RNA polymerase (RNAP) and the anti-terminator NusA. Although NusA does not bind directly to DNA, but rather to RNAP and/or to the nascent transcript, we demonstrate that NusA interacts with RNAP ubiquitously throughout the chromosome, ...[more]