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Transcription profile analysis of S. cerevisiae ZTW1 wild-type and mutant strains

ABSTRACT: We report the application of single-molecule-based sequencing technology for transcription profile analysis of two S. cerevisiae strains. By combining the whole genome sequence of these strains,we sought to explore the effects of genomic structure variations on the transcription diversities.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE40905 | GEO | 2012/10/10

SECONDARY ACCESSION(S): PRJNA175825

REPOSITORIES: GEO

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Transcription profile analysis of S. cerevisiae ZTW1 wild-type and mutant strains

Project description:We report the application of single-molecule-based sequencing technology for transcription profile analysis of two S. cerevisiae strains. By combining the whole genome sequence of these strains,we sought to explore the effects of genomic structure variations on the transcription diversities. Comparsion of transcription profiles in S. cerevisiae strains

2012-10-10 | E-GEOD-40905 | biostudies-arrayexpress

Transcription profile analysis of S. cerevisiae strains

Project description:We report the application of single-molecule-based sequencing technology for transcription profile analysis of S. cerevisiae strains with different genetic background. By combining the whole genome sequence of these strains, we sought to explore the effects of genome mutations on the transcription diversities.

2011-09-10 | GSE31601 | GEO

Transcription profile analysis of S. cerevisiae strains

2011-09-10 | E-GEOD-31601 | biostudies-arrayexpress

YHJ8 RNA-seq

Project description:We report the application of next-generation sequencing technology for transcription profile analysis of S. cerevisiae strains with different genetic background. By combining the whole genome sequence of these strains, we sought to explore the effects of genome mutations on the transcription diversities.

2014-06-16 | GSE54433 | GEO

YHJ8 RNA-seq

2014-06-16 | E-GEOD-54433 | biostudies-arrayexpress

Comparative Genomic Hybridization of S. cerevisiae industrial and laboratory strains

2011-09-15 | GSE31872 | GEO

Targeted proteome analysis of the central carbon metabolism related enzymes in S. cerevisiae mutant strains

Project description:Expression profiles of 110 the central metabolism-related enzymes were obtained by the selected reaction monitoring (SRM) assay methods using LC-MS/MS from the wild type (BY4742), a GCR2 gene deletion strain, and 29 single-gene deletion strains lacking enzyme genes responsible for central carbon metabolism (including CIT1, ENO1, FBP1, GCR2, GND1, GPD1, GPM2, HOR2, HXK1, HXK2, IDH1, IDH2, IDP1, LPD1, MAE1, MDH1, MDH2, PDA1, PDC1, PFK1, PYC2, RPE1, TAL1, TDH1, TDH2, TDH3, TKL1, TPS1, TPS2, and ZWF1 genes). The central carbon metabolism is strictly controlled by modulation of enzyme expressions to maintain an essential system of living organisms. In this study, metabolic safety mechanisms in the model organism, Saccharomyces cerevisiae, were investigated by direct determination of enzyme expression levels. Targeted proteome analysis of 31 S. cerevisiae wild type and mutant strains revealed that at least 30% of the observed variations in enzyme expression levels could be explained by global regulatory mechanisms. Co-expression analysis revealed that expression levels of enzymes involved in trehalose metabolism and glycolysis changed in a coordinated manner under the control of the transcription factors for global regulation.

2017-03-22 | PXD004714 | JPOST Repository

Variations in stress sensitivity and genomic expression in diverse S. cerevisiae strains

Project description:This SuperSeries is composed of the following subset Series: GSE10267: Variations in stress sensitivity and genomic expression in diverse S. cerevisiae strains (CGH) GSE10268: Variations in stress sensitivity and genomic expression in diverse S. cerevisiae strains (gene expression) Keywords: SuperSeries Refer to individual Series

2008-09-05 | E-GEOD-10269 | biostudies-arrayexpress

CGH of natural Saccharomyces cerevisiae strains

Project description:Comparative Genomic Hybridization of natural Saccharomyces cerevisiae strains vs lab reference strains.

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Comparative Genomic Hybridization of S. cerevisiae YJS329 and BYZ1

Project description:The environmental stresses and inhibitors encounted by Saccharomyces cerevisiae strains are main limiting factors in bioethanol fermentation. Investigation of the molecular mechanisms underlying the stresses-related phenotypes diversities within and between S. cerevisiae populations could guide the construction of yeast strains with improved stresses tolerance and fermentation performances. Here, we explored the genetic characteristics of the bioethanol S. cerevisiae strain YJS329, and elucidated the genetic variations correlated with its advantaged traits (higher ethanol yield under sever conditions and better tolerance to multiple stresses compared to an S288c derived laboratory strain BYZ1). Firstly, pulse-field gel electrophoresis combined with array-comparative genomic hybridization was used to compare the genome structure of YJS329 and the laboratory strain BYZ1. Yeast cells were cultured in YPD medium. Genome DNA of YJS329 and BYZ1 was isolated and sonicated. The average length of DNA fragments was 200-1000bp. The shearing DNA was labeled with Cy5/Cy3 and hybridized to NimbleGen S.cerevisiae Whole-Genome Tiling arrays, which is single array design containing all chromosomes with 32bp median probe spacing and totally covered by ~385,000 probes. Scanning was performed with the Axon GenePix 4000B microarray scanner.

2011-09-14 | E-GEOD-31872 | biostudies-arrayexpress

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