Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiles in human alveolar epithelial cell line exposure to impurity-free single-wall carbon nanotubes

ABSTRACT: To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the molecular level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physico-chemical properties of impurity-free single-wall carbon nanotubes (SWCNTs).

ORGANISM(S): Homo sapiens

PROVIDER: GSE41101 | GEO | 2012/09/25

SECONDARY ACCESSION(S): PRJNA175807

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Gene expression profiles in rat alveolar macrophages exposure to impurity-free single-wall carbon nanotubes

2014-09-11 | GSE61319 | GEO

Gene expression profiles in rat lung following intratracheal instillation with impurity-free single-wall carbon nanotubes

2014-09-17 | GSE61483 | GEO

Gene expression profiles in rat lung following intratracheal instillation with impurity-free single-wall carbon nanotubes

Project description:To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the transcriptional level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physicochemical properties of impurity-free single-wall carbon nanotubes (SWCNTs). We have prepared two types of dispersed the SWCNTs, namely relatively small bundles and a short linear shape (CNT-1) and large bundles and a long linear shape (CNT-2), and attempted to characterize time-dependent changes in the gene expression of lung tissues until 90 days after intratracheal instillation with SWCNTs suspensions at 0.4 mg injected dose per rat. Groups of nine-week-old male Wistar rats (n= 4 per group/ time point) were intratracheally instilled with single-wall carbon nanotubes (SWCNTs) suspended in 0.4 ml of 1.0mg/mL bovine serum albumin (BSA) as a single injection 0.4 mg SWCNTs/ rat. Control groups received 1.0mg/mL BSA (vehicle control). After intratracheal instillation treatment, rats were housed within polycarbonate cages at a controlled temperature of 22 M-BM-0C with a chow diet ad libitum, and dissected at 1day, 3 days, 7 days, 30 days, and 90 days post-instillation. Right lungs of anesthetized rats were perfused with physiological saline, excised, and used for DNA microarray analysis.

2014-09-17 | E-GEOD-61483 | biostudies-arrayexpress

Gene expression profiles in rat alveolar macrophages exposure to single carbon nanotubes II

2014-09-11 | E-GEOD-61319 | biostudies-arrayexpress

Gene expression profiles in human alveolar epithelial cell line exposure to single carbon nanotubes

Project description:To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the molecular level, we have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish characterization of physico-chemical properties of single-wall carbon nanotubes (SWCNTs). Three kinds of single-wall carbon nanotubes (SWCNTs), CNT-1, CNT-2 or CNT-3 induced gene expression in human alveolar epithelial cell lines were measured at 24 and 48 hours exposure to doses of 90.8Î¼g/mL (CNT-1), 109.0Î¼g/mL (CNT-2), and 77.0Î¼g/mL (CNT-2). Three independent experiments were performed at each time (24 or 48 hours) using different untreated control for each experiment (n=4).

2012-09-25 | E-GEOD-41101 | biostudies-arrayexpress

Gene expression profiles in rat lung following intratracheal instillation with short size single-wall and multi-wall carbon nanotubes

Project description:To further development of our gene expression approach to assess the effects of manufactured nanomaterials at the transcriptional level, we have employed whole genome microarray expression profiling to discuss the differences of the pulmonary and pleural Groups of nine-week-old male Wistar rats (n = 4 per group/ time point) were intratracheally instilled with short SWCNTs and MWCNTs suspended in 0.4 mL of 10mg/mL bovine serum albumin (BSA) as a single injection, respectively. Control groups received 10mg/

2015-11-19 | E-GEOD-75148 | biostudies-arrayexpress

Gene expression profiles in rat alveolar macrophages exposure to multi-walled carbon nanotubes

Project description:To evaluate the biological effects at the transcriptional level of manufactured nanomaterials, we performed whole genome microarrays of rat alveolar macrophages (NR8383) exposed to multi-walled carbon nanotubes (MWCNTs) with different physicochemical properties.

2019-09-07 | GSE137008 | GEO

Gene expression profiles in rat lung following intratracheal instillation with cellulose nanofibrils and multi-walled carbon nanotubes

Project description:To evaluate the biological effects at the transcriptional level of manufactured nanomaterials, whole genome microarray analysis of rat lungs intratracheally instilled with cellulose nanofibrils (CNFs) with different physicochemical properties or multi-walled carbon nanotubes (MWCNTs) were performed.

2020-07-09 | GSE154013 | GEO

Gene expression profiles in rat lung following intratracheal instillation with single-wall carbon nanotubes

Project description:Gene expression profiling of the rat lung following intratracheal instillation with single-wall carbon nanotubes (SWCNTs) was employed to gain insights into these molecular events. We attempted to characterize time-dependent changes in the gene expression until 754 days after intratracheal instillation with SWCNTs suspensions at 0.2 mg (L-SWCNT) and 0.4 mg (H-SWCNT) injected dose per rat, and to identify the shift from the acute-phase to the chronic-phase phase on the basis of evaluation at the molecular level.

2013-09-07 | GSE50664 | GEO

Effects of residual metals contained in single-wall carbon nanotubes on cellular response in rat alveolar macrophages and human alveolar epithelial cell line

Project description:Gene expression profiling of the rat alveolar macrophages (NR8383) and human alveolar epithelial cell line (A549) exposure to iron-enriched pristine single-wall carbon nanotubes (SWCNTs) or their purified SWCNTs were employed to gain insights at the transcriptional level.

2015-10-02 | GSE72569 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data