Analysis of global transcriptional response of Mycobacterium tuberculosis H37Rv to the natural compound ethyl p-methoxycinnamate

ABSTRACT: Gene expression profiling analysis was performed after exposing M. tuberculosis H37Rv to EPMC for 24 and 48 hours. Significant changes in expression levels were observed in the genome in response to the drug. Analysis of the data carried out by studying the expression pattern at the level of pathways, indicated that several pathways including amino sugar and nucleotide sugar metabolism, linoleic acid metabolism, fructose and mannose metabolism, galactose metabolism, lysine degradation pathways were significantly upregulated upon exposure to EPMC, while the pathways involved primarily in the mycobacterial cell wall biosynthesis - the mycolic acid biosynthesis and D-alanine metabolism were significantly downregulated

ORGANISM(S): Mycobacterium tuberculosis H37Rv

PROVIDER: GSE41582 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA177582

REPOSITORIES: GEO