Expression data from HeLa cells treated with Casiopeina Cas-II-gly

ABSTRACT: Copper-based chemotherapeutic compounds Casiopeinas, have been presented as able to promote selective programmed cell death in cancer cells, thus being proper candidates for targeted cancer therapy. DNA fragmentation and apoptosis -in a process mediated by reactive oxygen species- for a number of tumor cells, have been argued to be the main mechanisms. However, a detailed functional mechanism (a model) is still to be defined and interrogated for a wide variety of cellular conditions; before establishing settings and parameters needed for their wide clinical application. Microarrays were used to determine the expression profile from HeLa cells in order to propose a model for the role played by intrinsic apoptosis triggered by the oxidative stress caused by Cas-II-gly.

ORGANISM(S): Homo sapiens

PROVIDER: GSE41827 | GEO | 2012/10/31

SECONDARY ACCESSION(S): PRJNA178551

REPOSITORIES: GEO