Genomics

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Longitudinal expression data from CD8+ T cells responding to LCMV-Armstrong or LCMV-Clone 13


ABSTRACT: During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections, CD8+ T cells become “exhausted” and have poor effector function, express multiple inhibitory receptors, possess low proliferative capacity, and cannot persist without antigen. To compare the development of functional memory T cells with poorly functional exhausted T cells, we generated longitudinal transcriptional profiles for each.

ORGANISM(S): Mus musculus

PROVIDER: GSE41867 | GEO | 2012/11/23

SECONDARY ACCESSION(S): PRJNA178355

REPOSITORIES: GEO

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