Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data of differentiated human erythroid cells with or without Tranylcypromine (TC) treatment

ABSTRACT: We found that LSD1 inhibition by a monoamine oxidase inhibitor, tranylcypromine (TC), could enhance fetal gamma globin expression. Global effects of TC on erythroid expession were conducted by HG-U219 array strips.

ORGANISM(S): Homo sapiens

PROVIDER: GSE42078 | GEO | 2013/02/16

SECONDARY ACCESSION(S): PRJNA179085

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Expression data of differentiated human erythroid cells with or without Tranylcypromine (TC) treatment

Project description:We found that LSD1 inhibition by a monoamine oxidase inhibitor, tranylcypromine (TC), could enhance fetal gamma globin expression. Global effects of TC on erythroid expession were conducted by HG-U219 array strips. Primary human erythroid cells, which differentiated from CD34+ cells for 8 days, were harvested before or and after TC treatment (0.5 ÂµM, 1.5 ÂµM or 5 ÂµM) for the gene expression analysis.

2013-02-16 | E-GEOD-42078 | biostudies-arrayexpress

Escovopsis sp. TC strain:TC

Project description:Escovopsis sp. TC strain:TC Genome sequencing and assembly

| PRJNA388866 | ENA

Alicyclobacillus sp. TC strain:TC

Project description:Alicyclobacillus sp. TC strain:TC Genome sequencing and assembly

| PRJNA562382 | ENA

Transcriptome of thyroid cancer (TC) cells after coculture with TC-induced macrophages

Project description:RNA sequencing data of TPC-1 cells (TC cell line) after co-culture with TC-induced macrophages. We used an in vitro co-culture model of a human TC cell line, TPC1 (RET/PTC rearrangement), and human primary monocytes.

2020-09-21 | GSE120391 | GEO

Expression data from isolated endothelial cells from glioblastoma and normal brain cultured on Matrigel

Project description:We compared gene expressions between CD31-positive cells from glioblastoma (TECs) and endothelial cells from normal brain (NECs) In this dataset, expression data obtained from Affymetrix Human Genome U219 Array (HG-U219) are presented.

2022-05-18 | GSE137901 | GEO

Expression data from isolated endothelial cells from glioblastoma and normal brain cultured as monolayer on gelatin

2022-05-18 | GSE137900 | GEO

Genome wide chromatin changes in TC-32 and TC-71 Ewing sarcoma cell lines.

Project description:We performed ChIPseq on histone modification marks, transcriptional factors and chromatin architectural proteins in TC-32 and TC-71 Ewing sarcoma cell lines.

2019-08-07 | GSE115250 | GEO

Enterococcus sp. E843-TC isolate:E843-TC

Project description:Enterococcus sp. E843-TC isolate:E843-TC Genome sequencing

| PRJNA755459 | ENA

Changes of gene expression patterns of Mouse TC-1 cell lines responding to Interferon-gamma [TC-1 cell line]

Project description:We report the differences of gene expression pattern of Mouse TC-1 cell lines responding to Interferon-gamma. TC-1 cell lines were treated with 20ng/ml of Interferon-gamma for 72 hours and gathered for RNA seq. We found that in response to Interferon-gamma, TC-1 cell lines expressed increased amounts of RNA related to immune responses.

2020-08-22 | GSE156606 | GEO

Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping

Project description:Monoamine oxidases MAOA and MAOB catalyze important cellular functions such as the deamination of neurotransmitters. Correspondingly, MAO inhibitors are used for the treatment of severe neuropsychiatric disorders such as depression. A commonly prescribed drug against refractory depression is tranylcypromine, however, the side effects are poorly understood. In order to decipher putative off-targets, we synthesized two tranylcypromine probes equipped with either an alkyne moiety or an alkyne-diazirine minimal photocrosslinker for in situ proteome profiling. Surprisingly, LC-MS/MS analysis revealed low enrichment of MAOA and relatively promiscuous labeling of proteins. Photoprobe labeling paired with fluorescent imaging studies revealed lysosomal trapping which could be largely reverted by the addition of lysosomotropic drugs.

2020-10-20 | PXD018580 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data