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Comparative intraindividual transcriptome analysis of B-precursor ALL of childhood

ABSTRACT: The objective of this study was the assessment of transcriptional dysregulation in particular with regard to B-cell differentiation factors. Most studies focus on cross-section analyses of various leukemia subtypes to identify differentially regulated genes lacking suitable reference models. Here we applied comparative intraindividual transcriptome analysis of B-precursor ALL of childhood, which introduces a side-by-side analysis of leukemic cells and matched normal lymphoblasts from the same individual in complete continuous remission after the end of re-induction therapy. This approach reduces noise by eliminating interindividual variability.

ORGANISM(S): Homo sapiens

PROVIDER: GSE42221 | GEO | 2013/09/17

SECONDARY ACCESSION(S): PRJNA179347

REPOSITORIES: GEO

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