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Host response in the lung to influenza infection with PR8, VN or X31 strains at 12, 16 and 24 hours

ABSTRACT: Array analysis of total lung RNA obtained from mice 12,16,24 h post infection with influenza. Strains used were Mock, PR8, X31, VN62 (1x10^5pfu)

ORGANISM(S): Mus musculus

PROVIDER: GSE42285 | GEO | 2013/03/31

SECONDARY ACCESSION(S): PRJNA180998

REPOSITORIES: GEO

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Host response in the lung to influenza infection with PR8, VN or X31 strains at 12, 16 and 24 hours

Project description:Array analysis of total lung RNA obtained from mice 12,16,24 h post infection with influenza. Strains used were Mock, PR8, X31, VN62 (1x10^5pfu) Time Point: 12, 16, 24 h post infection (Mock, PR8, X31, VN62); Mock group has three biological replicates, virally infected groups have nine replicates.

2013-03-31 | E-GEOD-42285 | biostudies-arrayexpress

SBRI_AA Host response in the lung to influenza infection with PR8, VN or X31 strain at 12 hours.

Project description:Array analysis of total lung RNA obtained from mice 12 h post infection with influenza. Strains used were Mock, PR8, X31, VN6+2 (1x10^5pfu)

2012-09-26 | GSE37245 | GEO

SBRI_AA Host response in the lung to influenza infection with PR8, VN or X31 strain at 12 hours.

Project description:Array analysis of total lung RNA obtained from mice 12 h post infection with influenza. Strains used were Mock, PR8, X31, VN6+2 (1x10^5pfu) Time Point: 12 h post infection (Mock, PR8, X31, VN); Mock group has four biological replicates, virally infected groups have five replicates. Total samples: 19.

2012-09-26 | E-GEOD-37245 | biostudies-arrayexpress

SBRI_AB Host response in primary mouse tracheal epitelial cells (mTEC) to influenza infection with PR8, VN or X31 at MOI of 0.015 at 12 hours

Project description:Array analysis of total RNA from mTECs 12 h post infection with influenza. Strains used were Mock, PR8, X31, VN6+2 (MOI 0.015) Time Point: 12 h post infection (Mock, PR8, X31, VN) MOI 0.015; in biological triplicates. Total samples: 12.

2012-09-26 | E-GEOD-37246 | biostudies-arrayexpress

SBRI_AC Host response in primary mouse tracheal epitelial cells (mTEC) to influenza infection with PR8, VN or X31 at MOI of 3 at 12 hours

Project description:Array analysis of total RNA from mTECs 12 h post infection with influenza. Strains used were Mock, PR8, X31, VN6+2 (MOI 3) Time Point: 12 h post infection (Mock, PR8, X31, VN) MOI 3.0; in biological triplicates. Total samples: 12.

2012-09-26 | E-GEOD-37247 | biostudies-arrayexpress

SBRI_AC Host response in primary mouse tracheal epitelial cells (mTEC) to influenza infection with PR8, VN or X31 at MOI of 3 at 12 hours

Project description:Array analysis of total RNA from mTECs 12 h post infection with influenza. Strains used were Mock, PR8, X31, VN6+2 (MOI 3)

2012-09-26 | GSE37247 | GEO

SBRI_AB Host response in primary mouse tracheal epitelial cells (mTEC) to influenza infection with PR8, VN or X31 at MOI of 0.015 at 12 hours

Project description:Array analysis of total RNA from mTECs 12 h post infection with influenza. Strains used were Mock, PR8, X31, VN6+2 (MOI 0.015)

2012-09-26 | GSE37246 | GEO

Role of IFITM3 during primary influenza infection and reinfection

Project description:WT or IFITM3-KO mice were infected with PR8 H1N1 influenza virus and reinfected with X31 H3N2 influenza virus

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Expression data from immature pDC and pDC activated with CpG 1826 and influenza virus PR8

2007-12-13 | GSE7831 | GEO

Transcription profiling of mouse immature pDC and pDC activated with CpG 1826 and influenza virus PR8

Project description:CpG 1826 binds to Toll-like receptor (TLR)9, whereas influenza virus PR8 activates pDC via TLR7. Differential stimulation of pDCs is expected to result in unique activation mechanism(s) leading to a different phenotypically and functionally matured pDC; We used microarrays to detail the global programme of gene expression underlying the maturation process of pDC activated with CpG 1826 and influenza virus PR8. We identified a distinct expression profile of upregulated immunomediators. Experiment Overall Design: Sorted pDCs were cultured for 1h and 4hs in medium control or with 5 Âµg/ml CpG 1826 or 300 HAU/ml purified influenza A/PR/8 virus. The first experiment (e1) included pDC in media and stimulated with CpG for 4h. In two other independent experimental batches (e2 and e3), we obtained samples of sorted pDC cultured in medium alone (med), and with CpG or PR8 (flu) for 1h and 4h. RNA extraction was performed using the RNeasy Kit (Qiagen) and hybridization on Affymetrix microarrays was performed using standard protocols. We sought to obtain homogeneous populations of pDCs at different time points under defined activation conditions in order to decipher the temporal resolution of expression profiles during the process of their maturation.

2008-06-15 | E-GEOD-7831 | biostudies-arrayexpress

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