Transcriptomics

Dataset Information

0

Comparison of Bleo, Asthma, TH2 and Infection Models


ABSTRACT: Disease-Specific Gene Expression Profiling in Multiple Models of Lung Disease We profiled lung gene expression in 12 mouse models of infection, allergy, and lung injury. A total of 24 transcripts, including many involved in inflammation and immune activation, were differentially expressed in a substantial majority (9 or more) of the models. Expression patterns distinguished three groups of models: (1) bacterial infection (n = 5), with changes in 89 transcripts, including many related to nuclear factor-B signaling, cytokines, chemokines, and their receptors; (2) bleomycin-induced diseases (n = 2), with changes in 53 transcripts, including many related to matrix remodeling and Wnt signaling; and (3) T helper cell type 2 (allergic) inflammation (n = 5), with changes in 26 transcripts, including many encoding epithelial secreted molecules, ion channels, and transporters.

ORGANISM(S): Mus musculus

PROVIDER: GSE4231 | GEO | 2006/12/31

SECONDARY ACCESSION(S): PRJNA94883

REPOSITORIES: GEO

Similar Datasets

2006-12-30 | E-GEOD-4231 | biostudies-arrayexpress
2008-06-13 | GSE5555 | GEO
2016-12-28 | GSE92938 | GEO
2020-12-23 | GSE163740 | GEO
2008-10-18 | E-GEOD-5555 | biostudies-arrayexpress
2016-10-27 | GSE84152 | GEO
2014-11-14 | E-GEOD-60537 | biostudies-arrayexpress
2010-03-09 | E-GEOD-19204 | biostudies-arrayexpress
2011-06-01 | GSE19030 | GEO
2010-08-23 | GSE18712 | GEO